drl-1 : sod-1 : sod-2 : sod-4 : sod-5

"We measured the total cellular ROS in mekk-3 RNAi worms and found that the levels were significantly lower than that of control RNAi-treated worms, comparable to the ROS generated in eat-2(ad1116) (Fig. 4E). It appears that the reduced ROS levels are a result of metabolic shift to beta-oxidation and not due to active ROS detoxification. This is supported by gene expression profiling by microarray and qRT-PCR analysis where none of the five worm superoxide dismutase genes were significantly upregulated when mekk-3 is knocked down (Fig. S6D)."

Interaction involving tert-Butylhydroperoxide

"Those oxidant-modified cysteines might also contribute to ROS-induced DAF-16 translocation in to the nucleus."

drl-1 : sod-3

"We measured the total cellular ROS in mekk-3 RNAi worms and found that the levels were significantly lower than that of control RNAi-treated worms, comparable to the ROS generated in eat-2(ad1116) (Fig. 4E). It appears that the reduced ROS levels are a result of metabolic shift to beta-oxidation and not due to active ROS detoxification. This is supported by gene expression profiling by microarray and qRT-PCR analysis where none of the five worm superoxide dismutase genes were significantly upregulated when mekk-3 is knocked down (Fig. S6D)."

Interaction involving Hydrogen Peroxide

"Those oxidant-modified cysteines might also contribute to ROS-induced DAF-16 translocation in to the nucleus."

atad-3 : mics-1

"MICS-1 interacts with ATAD-3 and its depletion promotes longevity and lowers heat stress-induced ROS production in C. elegans."

atad-3 : mics-1

"MICS-1 interacts with ATAD-3 and its depletion promotes longevity and lowers heat stress-induced ROS production in C. elegans."

Acetylcysteine : nduf-7

"Elevated ROS levels appear essential for both the UPRmt activation and lifespan elongation in the nduf-7(et19) mutant because these phenotypes are abrogated by NAC, a hydrophilic antioxidant against all types of ROS (Aruoma et al. 1989; Benrahmoune et al. 2000; Yang and Hekimi 2010a) (Figure 6C, Figure 7)."

Acetylcysteine : nduf-7

"Elevated ROS levels appear essential for both the UPRmt activation and lifespan elongation in the nduf-7(et19) mutant because these phenotypes are abrogated by NAC, a hydrophilic antioxidant against all types of ROS (Aruoma et al. 1989; Benrahmoune et al. 2000; Yang and Hekimi 2010a) (Figure 6C, Figure 7)."

1-butyl-3-methylimidazolium : sod-3

"After 12 h exposure, the mortality, ROS and lipofuscin formation, expression of SOD-3::GFP in C. elegans, were determined... The ROS and lipofuscin levels, and expression of SOD-3::GFP following the four ILs treatments, drastically increased by about 2.5, 1.4 and 1.5-fold compared with the control, respectively (Fig. 1B-D)."

1-Dodecyl-3-methyl-imidazolium bromine : sod-3

"After 12 h exposure, the mortality, ROS and lipofuscin formation, expression of SOD-3::GFP in C. elegans, were determined... The ROS and lipofuscin levels, and expression of SOD-3::GFP following the four ILs treatments, drastically increased by about 2.5, 1.4 and 1.5-fold compared with the control, respectively (Fig. 1B-D)."