torsion dystonia-associated protein, torsinA : xbp-1

Spliced xbp-1 levels increased in response to tunicamycin in the absence of torsinA, whereas animals expressing WT torsinA maintained xbp-1 mRNA at the lower, unstressed level, even in the presence of stressor.

Expression of hepatitis B virus protein HBx : clp-1

"Most hids mutations not only suppressed embryonic lethality caused by global expression of HBx but also reduced or blocked ectopic neuronal death in smIs98 animals (Fig. S3B), suggesting that they affect either the apoptotic or the necrotic pathway or both (Fig. S3B)."

Expression of hepatitis B virus protein HBx : ced-9

"However, unlike egl-1(lf), ced-4(lf), and ced-3(lf) mutations that partially block HBx-induced cell death, ced-9(n1950gf) completely inhibited HBx-induced touch cell death (Fig. 2A) and embryonic lethality (Fig. 1B)."

Expression of hepatitis B virus protein HBx : ced-3

"To determinethe nature of HBx-induced cell death, we introduced the PhspHBx transgenes into animals defective in ced-3, which encodes a caspase essential for apoptosis (21), or animals defectivein mec-6, which is important for necrosis (22). A strong loss-of-function (lf) mutation in ced-3(n2433) or mec-6(e1342) partially suppressed embryonic lethality caused by HBx overexpression (Fig. 1B), indicating that both apoptotic and necrotic cell death contributes to lethality of HBx transgenic embryos."

Expression of hepatitis B virus protein HBx : mec-6

"To determinethe nature of HBx-induced cell death, we introduced the PhspHBx transgenes into animals defective in ced-3, which encodes a caspase essential for apoptosis (21), or animals defectivein mec-6, which is important for necrosis (22). A strong loss-of-function (lf) mutation in ced-3(n2433) or mec-6(e1342) partially suppressed embryonic lethality caused by HBx overexpression (Fig. 1B), indicating that both apoptotic and necrotic cell death contributes to lethality of HBx transgenic embryos."

Expression of hepatitis B virus protein HBx : ced-4

"Most hids mutations not only suppressed embryonic lethality caused by global expression of HBx but also reduced or blocked ectopic neuronal death in smIs98 animals (Fig. S3B), suggesting that they affect either the apoptotic or the necrotic pathway or both (Fig. S3B)."

Expression of hepatitis B virus protein HBx : mec-6

"Most hids mutations not only suppressed embryonic lethality caused by global expression of HBx but also reduced or blocked ectopic neuronal death in smIs98 animals (Fig. S3B), suggesting that they affect either the apoptotic or the necrotic pathway or both (Fig. S3B)."

Expression of hepatitis B virus protein HBx in touch cells : ced-4

"Loss of egl-1, ced-3, or ced-4 partially suppressed HBx-induced cell death (from 50% to 22-26% PLM death; Fig. 2A), indicating that HBx induces cell death partly through the apoptotic pathway."

Expression of hepatitis B virus protein HBx in touch cells : clp-1

"Most hids mutations not only suppressed embryonic lethality caused by global expression of HBx but also reduced or blocked ectopic neuronal death in smIs98 animals (Fig. S3B), suggesting that they affect either the apoptotic or the necrotic pathway or both (Fig. S3B)."

Expression of hepatitis B virus protein HBx in touch cells : cyn-1

"Similarly, a deletion mutation (tm4171) in cyn-1, which encodes the C. elegans cyclophilin D homolog, reduced the percentage of missing PLMs in smIs98 animals to 17% (Fig. S1C)."