ced-3 : sacy-1

Using DIC microscopy, we observed gamete degeneration in 99% of sacy-1(tm5503); ced-3(n717) adult hermaphrodite gonad arms (n = 150). We observed that acridine orange stains early degenerating gametes in the proximal gonad of sacy-1(tm5503); ced-3(n717) double mutants, as wellas sacy-1(tm5503) single mutant hermaphrodites.

ced-3 : lin-28

"CED-3 cleavage of LIN-28 generates an Arg/N-End rule N-degron."

mig-10 : unc-34

"The N-terminal 118 amino acids of MIG-10A (MIG-10A-N) binds the 60 KD UNC-34."

clp-1 : mec-4

Dr. N. Tavernarakis: suppression of neurodegeneration

cdc-37 : hsp-90

"CeCdc37 binds Hsp90 via its N-domain."

cdc-37 : hsp-90

"CeCdc37 binds Hsp90 via its N-domain."

lag-2 : unc-62

Only 40% of unc-62(RNAi) hermaphrodites displayed expression in P6.px (n=42) as compared to feeding vector control (100%, n=30).

air-1 : klp-7

"TPXL-1 N-terminal fragment (aa 1 - 63) stimulates AIR-1 phosphorylation of KLP-7 within the N-terminus and the C-terminus."

pod-2 : sams-1

SAMS-1 was significantly reduced (2.4-fold) by pod-2 RNAi treatment based on 2DE (n=2) and 2D DIGE (n=3) analyses.

tbx-8 : tbx-9

increased TBX-9 expression rescues the penetrance of a tbx-8(ok656) null mutation, 60% (n=164) compared with 35% (n=195), a 42% decrease.