"The Caenorhabditis elegans R-Smad DAF-8 partners with the nuclear hormone receptor NHR-69, a C. elegans ortholog of mammalian hepatocyte nuclear factor 4alpha (HNF4alpha)."
"After cloning and expressing Ce-PK-R in HEK293T cells,we found that it was activated by a neuropeptide from the C. elegans NLP-44 precursor (EC50 = 18 nM)."
In wild type, lin-32p::mRFP::unc-60A 3'UTR was intensely detected in every R(n).a + p. However, in plx-1 mutants, R(1).a + p, R(2).a + p and R(5).a + units displayed pronounced decreases in expression of mRFP.
In wild type, lin-32p::mRFP::unc-60A 3'UTR was intensely detected in every R(n).a + p. However, in smp-1smp-2 mutants, R(1).a + p, R(2).a + p and R(5).a + units displayed pronounced decreases in expression of mRFP.
Expression of mec-2-lacZ in the ALML/R, AVM, and PVM touch cells was greatly decreased (<5% of the cells stained); 67% of the PLML/R cells still stained in mec-3(u6).