"We also examined the lifespan phenotype following
vit-1/2 RNAi and observed a marked rescue of the lifespan defect (Mallick et al. 2020) in
pry-1(
mu38) (102% increase in mean lifespan). The wildtype animals showed a comparatively lower increase in the mean lifespan (16.6%) (Figures 1F and 1G). Overall, these findings show that
vit-2 functions downstream of
pry-1 to regulate both lipid levels and lifespan."