Interaction involving hlh-14

"To test whether hlh-14 mutants have extra T cells, we used a C50B6.8::gfp reporter. C50B6.8 is a C. elegans gene that is expressed in the ten hypodermal seam cells, including the T cells (Mounsey et al., 2002) (Fig. 5C)... With this GFP reporter, we observed that hlh-14 mutants often have extra GFP-expressing cells in the tail, presumably extra T (or T-like) cells (Fig. 5D)... Notably, these supernumerary T-like cells are smaller than normal T cells (Fig. 5D)."

lin-17 : lit-1

0% of animals exhibited T cell divisions with reversed polarity.

lin-17 : lit-1

0% of animals exhibited T cell divisions with reversed polarity.

egl-5 : sem-4

Ectopic egl-5 expression in the T lineage in sem-4 mutant animals began two cell divisions (in T.pp) after sem-4 expression would normally begin (in T).

daf-15 : vhl-1

VHL-1 interacts with DAF-15/RAPTOR in HEK 293 T cells.

lin-44 : lit-1

lit-1(t1512) suppresses the number of T cell divisions adopting reversed polarity.

ceh-20 : psa-3

In both daughters soon after T cell division as well as in the T cell, CEH-20 nuclear localization is regulated by psa-3, while at the late stage, CEH-20 nuclear localization in T.p, but not T.a, depends on psa-3 function.

lin-17 : wrm-1

In the wild-type T cell, WRM-1 always localized to the anterior cortex prior to cell division. The cortical localization of WRM-1 in lin-17 mutants was found to be often symmetrical throughout the cell cortex prior to T cell division.

lin-17 : lit-1

100% percent of animals exhibit symmetric T cell divisions, which is significantly increased compared to either single mutant.

lin-44 : lit-1

The percent of symmetric T cell divisions is significantly increased in the double mutant compared to either single mutant.