ddl-1 : ddl-2

ddl-1/ddl-2 double RNAi has an extended life span similar to both individual RNAi treatments, suggesting an asynthetic genetic interaction

Interaction involving zyg-1

"CPB of C. elegans ZYG-1, which forms a Z-shaped dimer containing an intermolecular beta-sheet with an extended basic surface patch."

hmgs-1 : ubc-13

"Knockdown of either UBA-5 or UBC-13 interactors resulted in an increased HMGS-1::GFP signal in comparison with an empty vector control (Fig 4B)."

ifet-1 : mex-3

"MEX-3 binds IFET-1, an eIF4E-binding protein."

aak-2 : daf-16

"AMPK phosphorylates DAF-16 in an AMP-dependent manner."

hmgs-1 : uba-5

"Knockdown of either UBA-5 or UBC-13 interactors resulted in an increased HMGS-1::GFP signal in comparison with an empty vector control (Fig 4B)."

atg-3 : vps-34

Both vps-34(h797) and atg-3(bp412) mutations resulted in an accumulation of embryonic cell corpses phenotype and double mutants did not have an enhanced phenotype

epg-6 : vps-34

Both vps-34(h797) and epg-6(bp242) mutations resulted in an accumulation of embryonic cell corpses phenotype and double mutants did not have an enhanced phenotype

fsn-1 : ppm-1.A

fsn-1; ppm-1 double mutants had an additive phenotype in the ALM neurons; however, an enhanced penetrance of big hooks was observed in fsn-1; ppm-

mir-228 : skn-1

RNAi directed against skn-1 leads to an alteration in mature levels of miR-228. skn-1(RNAi) leads to an increase in mir- 228::GFP expression.