F53A9.9 : exposure to Microbacterium nematophilium

"Because overlapping gene expression changes measured by qRT-PCR do not necessarily imply the involvement of the same tissues during infection with different pathogens, we further investigated the expression of clec-60::GFP (up-regulated by S. aureus and M. nematophilum, Figure S11A, B, C, D) and F53A9.8::GFP (up-regulated by S. aureus, M. nematophilum, and P. aeruginosa, Figure S11E, F, G, H)... F53A9.8::GFP was induced by all three pathogens in the intestine (Figure S11F, G, H) compared with E. coli controls (Figure S11E)."

Exposure to Pseudomonas aeruginosa : F53A9.9

"Because overlapping gene expression changes measured by qRT-PCR do not necessarily imply the involvement of the same tissues during infection with different pathogens, we further investigated the expression of clec-60::GFP (up-regulated by S. aureus and M. nematophilum, Figure S11A, B, C, D) and F53A9.8::GFP (up-regulated by S. aureus, M. nematophilum, and P. aeruginosa, Figure S11E, F, G, H)... F53A9.8::GFP was induced by all three pathogens in the intestine (Figure S11F, G, H) compared with E. coli controls (Figure S11E)."

F53A9.9 : Staphylococcus Aureus Infection

"Because overlapping gene expression changes measured by qRT-PCR do not necessarily imply the involvement of the same tissues during infection with different pathogens, we further investigated the expression of clec-60::GFP (up-regulated by S. aureus and M. nematophilum, Figure S11A, B, C, D) and F53A9.8::GFP (up-regulated by S. aureus, M. nematophilum, and P. aeruginosa, Figure S11E, F, G, H)... F53A9.8::GFP was induced by all three pathogens in the intestine (Figure S11F, G, H) compared with E. coli controls (Figure S11E)."

Interaction involving sqv-4

"Sedimentation velocity analysis of unliganded cUGDH reveals a distribution corresponding to a (M)onomer, (D)imer, (T)etramer,and (H)examer species."

caffeic acid phenethyl ester : hsp-16.2

The strain CL2070 (carrying hsp-16.2::gfp) which has been treated with 200 M CAPE overnight, started to glow rapidly even in 4 h after 2 h-heat shock, whereas the non-treated worm glowed only dimly in the same period.

Exposure to Pseudomonas aeruginosa : clec-60

"Because overlapping gene expression changes measured by qRT-PCR do not necessarily imply the involvement of the same tissues during infection with different pathogens, we further investigated the expression of clec-60::GFP (up-regulated by S. aureus and M. nematophilum, Figure S11A, B, C, D) and F53A9.8::GFP (up-regulated by S. aureus, M. nematophilum, and P. aeruginosa, Figure S11E, F, G, H). clec-60::GFP was induced by M. nematophilum and by S. aureus in the intestine (Figure S11C, D), and down-regulated by P. aeruginosa (Figure S11B) compared with nonpathogenic E. coli (Figure S11A)."

clec-60 : exposure to Microbacterium nematophilium

"Because overlapping gene expression changes measured by qRT-PCR do not necessarily imply the involvement of the same tissues during infection with different pathogens, we further investigated the expression of clec-60::GFP (up-regulated by S. aureus and M. nematophilum, Figure S11A, B, C, D) and F53A9.8::GFP (up-regulated by S. aureus, M. nematophilum, and P. aeruginosa, Figure S11E, F, G, H). clec-60::GFP was induced by M. nematophilum and by S. aureus in the intestine (Figure S11C, D), and down-regulated by P. aeruginosa (Figure S11B) compared with nonpathogenic E. coli (Figure S11A)."

Staphylococcus Aureus Infection : clec-60

"Because overlapping gene expression changes measured by qRT-PCR do not necessarily imply the involvement of the same tissues during infection with different pathogens, we further investigated the expression of clec-60::GFP (up-regulated by S. aureus and M. nematophilum, Figure S11A, B, C, D) and F53A9.8::GFP (up-regulated by S. aureus, M. nematophilum, and P. aeruginosa, Figure S11E, F, G, H). clec-60::GFP was induced by M. nematophilum and by S. aureus in the intestine (Figure S11C, D), and down-regulated by P. aeruginosa (Figure S11B) compared with nonpathogenic E. coli (Figure S11A)."

Ginkgo biloba extract EGb 761. : hsp-16.2

Upon induction by thermal stress, the GFP fluorescence is visible at the head of the worm, including the pharynx and the anterior nerve ring in the transgenic worm but not in the wild-type controls. The expression of hsp-16-2 induced by heat shock was significantly suppressed by 33% in CL2070 worms fed with EGb761. Exposure of the transgenic worms to 40 M juglone, an oxidative stressor, for 24 h generated higher hsp-16-2 expression than that induced by heat shock. Shorter exposure time to juglone also induced hsp-16-2 expression but to a lesser degree: an 11% and 30% induction were observed in worms exposed to juglone for 6 h and 12 h, respectively (24 h exposure set as 100%). The juglone-induced expression of hsp-16-2 was remarkably attenuated by 86% in worms pretreated with 100 g/ml EGb 761, compared with untreated controls (EGb761, GFP mean pixel density 180 vs. control GFP mean pixel density 25, n=120 worms, P<0.001). Similar results were obtained in worms exposed to a higher concentration of juglone (60 M).

egl-10 : gpb-1

"G-protein beta-subunits interact directly with G-protein gamma-subunits."