In contrast to what has been reported in mice, we observed elevated embryonic lethality in brc-1 and brd-1 null alleles [brc-1(xoe4), brd-1(xoe18) (Li et al. 2023; Li et al. 2018)], in combination with either hsr-9(ok759) (Ryu et al. 2013) or a new putative null allele hsr-9(xoe17) (Figure 1A).
In contrast to what has been reported in mice, we observed elevated embryonic lethality in brc-1 and brd-1 null alleles [brc-1(xoe4), brd-1(xoe18) (Li et al. 2023; Li et al. 2018)], in combination with either hsr-9(ok759) (Ryu et al. 2013) or a new putative null allele hsr-9(xoe17) (Figure 1A).
In contrast to what has been reported in mice, we observed elevated embryonic lethality in brc-1 and brd-1 null alleles [brc-1(xoe4), brd-1(xoe18) (Li et al. 2023; Li et al. 2018)], in combination with either hsr-9(ok759) (Ryu et al. 2013) or a new putative null allele hsr-9(xoe17) (Figure 1A).
In contrast to what has been reported in mice, we observed elevated embryonic lethality in brc-1 and brd-1 null alleles [brc-1(xoe4), brd-1(xoe18) (Li et al. 2023; Li et al. 2018)], in combination with either hsr-9(ok759) (Ryu et al. 2013) or a new putative null allele hsr-9(xoe17) (Figure 1A).
On the other hand, a hypomorphic brc-1 allele, brc-1(tm1145) (Li et al. 2018), in combination with hsr-9(xoe17) did not result in elevated embryonic lethality (Figure 1A).
"...We measured gene induction during exposure to live S. aureus, which causes pathogenesis, or heat-killed S. aureus, which does not (Figures 3G-I and S4C, E). Unexpectedly, all 10 biomarker genes were induced at least equally well on heat-killed S. aureus as on live S. aureus (Figure 6A)."