The LAM-1::GFP protein appears distributed uniformly to all basement membranes. In strong lam-3 loss-of-function mutants LAM-1::GFP is detected along the surfaces of the tissues, which are often deformed.
The LAM-1::GFP protein appears distributed uniformly to all basement membranes. In strong epi-1 loss-of-function mutants, LAM-1::GFP is detected in a punctuated pattern within cells.
Body-wall-muscle lateral ectopic membrane extensions (EMEs) induced by RNAi of lam-1 are strongly suppressed by the clr-1(e1745) loss-of-function mutation
Body-wall-muscle lateral ectopic membrane extensions (EMEs) induced by RNAi of lam-2 are partially suppressed by the let-60(n1046) gain-of-function mutation
Body-wall-muscle lateral ectopic membrane extensions (EMEs) induced by RNAi of lam-2 are strongly suppressed by the clr-1(e1745) loss-of-function mutation
Body-wall-muscle lateral ectopic membrane extensions (EMEs) induced by RNAi of lam-1 are partially suppressed by the let-60(n1046) gain-of-function mutation
lam-3 RNAi feeding had no effect in the wild-type (N2) background but significantly enhanced the lethality (embryonic and larval) and Vab phenotypes of pxn-2(ju432) partial loss-of-function mutants.