"In wild-type C. elegans embryos, AIR-2 localizes to the kinetochores of chromosomes in early mitosis, and to the central spindle and midbody in anaphase and telophase (Schumacher et al., 1998). In ZEN-4-depleted embryos, which lack dense microtubule bundles between the chromosome masses, AIR-2 localization is restricted to small microtubule bundles (Powers et al., 1998). Similarly, we observed that some microtubules were still labeled by anti-AIR-2 antibodies in CeCDC-14-depleted embryos (n = 5), even though no compact central spindles were assembled (Fig. 4 B, bottom)."