"When we examined LIN-12::GFP accumulation in
let-60(
n1046), a weakly activating Ras gain-of-function mutation (Beitel et al., 1990; Han et al.,1990), we observed that about 10% of hermaphrodites (5/50) display an alternating pattern of staining and non-staining VPCs (Fig. 6)... ectopic activation of the inductive signalling pathway may be sufficient to cause reduced LIN-12::GFP accumulation"