Individual loss of neither OSM-9 nor OCR-2 function affected response to 10mM quinine (Figure 1A), similar to our previous report (Ezak et al. 2010). Further,
osm-9 and
ocr-2 single mutants responded similarly to wild-type animals across the range of quinine concentrations tested (10mM- 1mM, Figure 1A). Only in the
osm-9 ocr-2 double mutant animals was a partial defect in quinine avoidance seen, at each concentration (Figure 1A); Similarly, in response to SDS only a partial avoidance defect was seen for
osm-9 and
ocr-2 single mutants at 0.1%- 0.001%, with the double mutant showing a somewhat greater defect at 0.001% (Figure 1C).