"The nuclear function of
eri-6/7-dependent siRNAs was further examined by NRDE-3 localization analysis in
eri-6/7 mutants at post-embryonic stages. Like in
eri-1 mutants, NRDE-3 fails to localize to the nucleus in
eri-6/7 mutants, suggesting that a subset or all 22G endogenous siRNAs dependent on
eri-6/7 direct NRDE-3 to the nucleus to mediate co-transcriptional gene silencing (Figure 4B)"