6 Interactions found (0.126 seconds)

let-60 : lin-39

"As a control, it was shown that the Overinduced phenotype caused by an activating mutation in the ras gene, let-60(n1046) (Beitel et al. 1990; Han et al. 1990) is also suppressed by lin- 39(n709ts)."

lin-45 : pry-1

"... 67% of animals carrying lin-45(n2018cs), a reduction- of-function mutation in the C. elegans raf gene (Han et al. 1993), were Underinduced or Vulvaless, whereas 51% of pry-1(mu38); lin-45(n2018cs) were Overinduced (Table 4; Fig 1)."

let-60 : pry-1

"... let-60(n1531) encodes a dominant-negative mutation in let-60 ras (Beitel et al. 1990; Han et al. 1990). A total of 56% of let-60(n1531)/+ animals show a Vulvaless phenotype at 25 degrees Celsius, whereas 38% of pry-1(mu38); let-60(n1531dn) animals show an Overinduced phenotype."

let-60 : lin-12

"When we examined LIN-12::GFP accumulation in let-60(n1046), a weakly activating Ras gain-of-function mutation (Beitel et al., 1990; Han et al.,1990), we observed that about 10% of hermaphrodites (5/50) display an alternating pattern of staining and non-staining VPCs (Fig. 6)... ectopic activation of the inductive signalling pathway may be sufficient to cause reduced LIN-12::GFP accumulation"

nhr-38 : sur-2

"In the suppressor screen, we utilized pleiotropic defects of cmk-1 mutants: cmk-1 mutants showed abnormally low expression of nhr-38 promoter-fused GFP, an AFD neuron-specific GFP marker (Satterlee et al., 2004). Therefore, we mutagenized cmk-1 mutants carrying nhr-38 promoter-fused GFP and found that a mutation in sur-2 gene that encodes the ortholog of human MED23, a subunit of transcription mediator complex (Singh and Han, 1995), restored the expression of the GFP marker in a cmk-1 mutant background (Figures S3A and S3B)."

cmk-1 : sur-2