Se(IV) treatment led to more significant activation of immune gene C29F3.7-1 in PA14-infected worms (Se + PA14) than in the uninfected control (Ctrl + PA14).
Se(IV) treatment led to more significant activation of immune gene irg-1 in PA14-infected worms (Se + PA14) than in the uninfected control (Ctrl + PA14).
Se(IV) treatment led to more significant activation of immune gene abf-1 in PA14-infected worms (Se + PA14) than in the uninfected control (Ctrl + PA14).
Se(IV) treatment led to more significant activation of immune gene hsf-1 in PA14-infected worms (Se + PA14) than in the uninfected control (Ctrl + PA14).
Se(IV) treatment led to more significant activation of immune gene lys-1 in PA14-infected worms (Se + PA14) than in the uninfected control (Ctrl + PA14).
Se(IV) treatment led to more significant activation of immune gene spp-1 in PA14-infected worms (Se + PA14) than in the uninfected control (Ctrl + PA14).
Muscles expressing the DOP-3::RFP and exposed to Se(IV), showed increased expression levels of DOP-3::RFP not observed in the muscles of water exposed animals.
Sequence inspection revealed that Region B contains four closely spaced Snail- binding sites, DNA-binding sites for members of the Snail family of zinc-finger transcription factors (Hemavathy et al., 2000). The core motif of three of these binding sites is completely conserved in C. briggsae (binding sites I, II and IV; 6/6 bases identical), and one of them has one base change in C. briggsae (binding site III; 5/6 bases identical). The sequence of binding sites I and II of C. elegans is a perfect match to the sequence of the core motif of a consensus Snail-binding site (5'-CACCTG-3') whereas the sequences of binding sites III and IV have one mismatch to the consensus sequence (5'- CATCTG-3' and 5'-CAGCTG-3', respectively). Binding of CES-1 to Region B was severely reduced after the introduction of point mutations that destroy the core motif of the four Snail-binding sites.
Sequence inspection revealed that Region B contains four closely spaced Snail- binding sites, DNA-binding sites for members of the Snail family of zinc-finger transcription factors (Hemavathy et al., 2000). The core motif of three of these binding sites is completely conserved in C. briggsae (binding sites I, II and IV; 6/6 bases identical), and one of them has one base change in C. briggsae (binding site III; 5/6 bases identical). The sequence of binding sites I and II of C. elegans is a perfect match to the sequence of the core motif of a consensus Snail-binding site (5'-CACCTG-3') whereas the sequences of binding sites III and IV have one mismatch to the consensus sequence (5'- CATCTG-3' and 5'-CAGCTG-3', respectively). Binding of CES-1 to Region B was severely reduced after the introduction of point mutations that destroy the core motif of the four Snail-binding sites.
Sequence inspection revealed that Region B contains four closely spaced Snail- binding sites, DNA-binding sites for members of the Snail family of zinc-finger transcription factors (Hemavathy et al., 2000). The core motif of three of these binding sites is completely conserved in C. briggsae (binding sites I, II and IV; 6/6 bases identical), and one of them has one base change in C. briggsae (binding site III; 5/6 bases identical). The sequence of binding sites I and II of C. elegans is a perfect match to the sequence of the core motif of a consensus Snail-binding site (5'-CACCTG-3') whereas the sequences of binding sites III and IV have one mismatch to the consensus sequence (5'- CATCTG-3' and 5'-CAGCTG-3', respectively). Binding of CES-1 to Region B was severely reduced after the introduction of point mutations that destroy the core motif of the four Snail-binding sites.