pei-1 : pei-2

PEI-2 interacts with PEI-1.; "BTB and BACK domains of PEI-2interact with PEI-1"

pei-1 : pei-2

PEI-2 interacts with PEI-1.; "BTB and BACK domains of PEI-2interact with PEI-1"

eat-2 : mdt-15

mdt-15 RNAi suppressed the life span extension of eat-2(ad1116) back to wild-type levels.

ceh-7 : egl-5

"Examination of ceh-7-gfp in egl-5 him-5 males did not show any expression in the rectal cells (Fig. 2D, E). As a control, we crossed the ceh-7-gfp array from the egl-5 him-5 animals back into him-5 and could observe restored expression in male tails."

fsn-1 : wdfy-3

"To determine if our new wdfy-3(cue30) allele also has this property, we analyzed PLM axon termination in wdfy-3(cue30); fsn-1(null) double mutants. We found that wdfy-3(cue30) also suppresses overextension caused by fsn-1 (Figure 1C). However, this suppression did not bring the overextension penetrance back to wildtype levels like the wdfy-3(ok912) allele (Figure 1C)."

lgg-1 : nhr-62

"Under normal conditions GFP::LGG-1 is cytoplasmic and diffuse in the worm's hypodermal seam cells, but under DR conditions, forms puncta which are associated with an increase in autophagy [20]. We observed a significant increase in the average number of GFP::LGG-1 puncta per seam cell in the eat-2 background, and found that nhr-62 RNAi suppressed puncta formation back to wild-type levels, suggesting that nhr-62 modulates autophagy up-regulation under DR (Figure 5D)."

eat-2 : lgg-1

"Under normal conditions GFP::LGG-1 is cytoplasmic and diffuse in the worm's hypodermal seam cells, but under DR conditions, forms puncta which are associated with an increase in autophagy [20]. We observed a significant increase in the average number of GFP::LGG-1 puncta per seam cell in the eat-2 background, and found that nhr-62 RNAi suppressed puncta formation back to wild-type levels, suggesting that nhr-62 modulates autophagy up-regulation under DR (Figure 5D)."

apl-1 : unc-108

The hypomorphic mutant unc-108(n3263) was crossed to the APL-1::GFP expressing strain. One of the head inter-neurons appeared to have a back-up of protein in the cell body. This aggregation of protein in a distinct compartment was also seen in ventral cord neurons. We then performed colocalization experiments by generating strains expressing APL-1::GFP and mCherry::UNC-108. Similar to the colocalization with RAB-5, APL-1 is found in overlapping puncta with UNC-108 in neurons, demonstrating APL-1 localization to the same compartment.

daf-11 : trx-1

At 25 deg C, but enhances the Daf-C at 15 deg C.

daf-11 : trx-1

At 15 deg C but suppresses the Daf-C phenotype of sa195 at 25 deg C.