osta-1 : rab-5

Although the velocities of each protein were unaffected in osta-1 mutants, both the anterograde and retrograde flux of GFP::RAB-5 was markedly increased. Approximately twice as many RAB-5 particles were found to be mobile in both the anterograde and retrograde directions in osta-1 mutants as in wild type. These observations suggest that OSTA-1 can be vesicle-associated and regulates the trafficking of RAB-5 vesicles in the AWB dendrite.

osta-1 : srbc-64

In osta-1 mutants, we observed increased accumulation of the SRBC-64 and SRG-36 fusion proteins at the periciliary membrane trafficking compartment in ASK and ASI, respectively.

osta-1 : srg-36

In osta-1 mutants, we observed increased accumulation of the SRBC-64 and SRG-36 fusion proteins at the periciliary membrane trafficking compartment in ASK and ASI, respectively.