somatic diversification of T cell receptor genes by N region addition

The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of T cell receptor genes. N regions are found at the V-D, D-D, V-J, and D-J recombinational junctions, depending on the T cell receptor gene.

T cell receptor V(D)J recombination

The process in which T cell receptor V, D, and J, or V and J gene segments, depending on the specific locus, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS).

somatic diversification of immune receptors by N region addition

The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin and T cell receptor genes. N regions are found at the V-D, D-D, V-J, and D-J recombinational junctions, depending on the immune receptor gene.

pyrimidine dimer repair

The repair of UV-induced T-T, C-T and C-C dimers.

polymeric immunoglobulin binding

Binding to a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes.

V(D)J recombination

The process in which immune receptor V, D, and J, or V and J gene segments, depending on the specific receptor, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS).

thymine/thymine mispair binding

Binding to a double-stranded DNA region containing a T/T mispair.

photoreactive repair

The repair of UV-induced T-T, C-T and C-C dimers by directly reversing the damage to restore the original pyrimidines.

aclacinomycin T methylesterase activity

Catalysis of the reaction: aclacinomycin T(1+) + H2O = 15-demethylaclacinomycin T + methanol + H+.

CD4-positive or CD8-positive, alpha-beta T cell lineage commitment

The process in which an immature T cell commits to CD4-positive T cell lineage or the CD8-positive lineage of alpha-beta T cells.