Rhino-Deadlock-Cutoff Complex

Protein complex found in Drosophila consisting of the gene products of cuff, del and rhi. It regulates the licensing of transcription of dual-strand PIWI interacting RNA (piRNA) source loci by binding to dual-strand-cluster chromatin, probably via the H3K9me3-binding activity of Rhi. Rhi binding brings the putative termination cofactor Cuff in close proximity to the nascent piRNA precursor transcript which it appears to protect from degradation.

hydrolase activity

Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.

pyrimidine dimer repair

The repair of UV-induced T-T, C-T and C-C dimers.

chemokine (C-C motif) ligand 21 binding

Binding to chemokine (C-C motif) ligand 21.

chemokine (C-C motif) ligand 7 binding

Binding to chemokine (C-C motif) ligand 7.

chemokine (C-C motif) ligand 5 binding

Binding to chemokine (C-C motif) ligand 5.

chemokine (C-C motif) ligand 19 binding

Binding to chemokine (C-C motif) ligand 19.

chemokine (C-C motif) ligand 12 binding

Binding to chemokine (C-C motif) ligand 12.

chemokine (C-C motif) ligand 2 binding

Binding to chemokine (C-C motif) ligand 2.

holocytochrome-c synthase activity

Catalysis of the reaction: holocytochrome c = apocytochrome c + heme.