cytosolic region

Any (proper) part of the cytosol of a single cell of sufficient size to still be considered cytosol.

cytoplasmic region

Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm.

primary cell wall

A plant cell wall that is still able to expand, permitting cell growth. Primary cell walls contain more pectin than secondary walls and no lignin is present.

'de novo' cotranslational protein folding

The process of assisting in the correct noncovalent assembly of the ribosome-bound nascent chains of a multidomain protein whilst other parts of the protein are still being translated.

fluconazole transmembrane transporter activity

Enables the transfer of fluconazole from one side of a membrane to the other. Fluconazole is an antifungal drug used for oral candidiasis and cryptococcal meningitis; it is still under study for treatment of vaginal candidiasis and other fungal infections.

Notch receptor processing, ligand-independent

The proteolytic cleavages to the Notch protein that occur prior to ligand binding. A primary cleavage event within the extracellular domain whilst the Notch protein in still in the secretory pathway, leads to the transportation of a processed heterodimer to the cell surface.

establishment of blood-nerve barrier

The establishment of the barrier between the perineurium of peripheral nerves and the vascular endothelium of endoneurial capillaries. The perineurium acts as a diffusion barrier, but ion permeability at the blood-nerve barrier is still higher than at the blood-brain barrier.

fluconazole transport

The directed movement of fluconazole into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fluconazole is an antifungal drug used for oral candidiasis and cryptococcal meningitis; it is still under study for treatment of vaginal candidiasis and other fungal infections.

first spliceosomal transesterification activity

Catalysis of the first transesterification reaction of spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, while it is still joined to the 3' exon.

obsolete first U12-type spliceosomal transesterification activity

OBSOLETE. Catalysis of the first transesterification reaction of U12-type spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, which is still joined to the 3' exon. The catalytic site is thought to be formed by U6atac snRNA and/or U2atac snRNA, and/or associated proteins.