wrn-1

Caenorhabditis elegans

Enables 3'-5' DNA helicase activity. Involved in DNA metabolic process; determination of adult lifespan; and response to ionizing radiation. Located in nucleoplasm and site of double-strand break. Expressed in several structures, including AWCL; AWCR; and germ line. Used to study Werner syndrome. Human ortholog(s) of this gene implicated in several diseases, including Werner syndrome; diffuse scleroderma; and senile cataract. Is an ortholog of human WRN (WRN RecQ like helicase).

K09D9.9

Caenorhabditis elegans

Is affected by several genes including etr-1; ash-2; and wrn-1 based on microarray and RNA-seq studies. Is affected by five chemicals including methylmercuric chloride; multi-walled carbon nanotube; and sucrose based on microarray and RNA-seq studies.

T28A11.4

Caenorhabditis elegans

Enriched in dopaminergic neurons; muscle cell; and ventral nerve cord based on tiling array and RNA-seq studies. Is affected by several genes including wrn-1; hpl-2; and npr-1 based on tiling array; RNA-seq; and microarray studies. Is affected by four chemicals including copper sulfate; multi-walled carbon nanotube; and rifampin based on microarray and RNA-seq studies.

C33B4.5

Caenorhabditis elegans

Enriched in neurons and sensory neurons based on RNA-seq studies. Is affected by several genes including wrn-1; drh-3; and emb-4 based on RNA-seq and microarray studies. Is affected by methylmercuric chloride based on microarray studies.

Y57E12B.1

Caenorhabditis elegans

Is affected by several genes including hsf-1; wrn-1; and hpl-1 based on microarray and RNA-seq studies. Is affected by five chemicals including methylmercuric chloride; Ag nanoparticles; and single-walled carbon nanotube based on microarray and RNA-seq studies.

W07G4.7

Caenorhabditis elegans

Is affected by several genes including lsm-1; wrn-1; and dpy-21 based on microarray and RNA-seq studies. Is affected by tryptophan and dafa#1 based on microarray studies. Is predicted to encode a protein with the following domain: Phospholipase A2-like.

Y116A8C.43

Caenorhabditis elegans

Enriched in neurons based on RNA-seq studies. Is affected by several genes including csr-1; wrn-1; and dlc-1 based on microarray and RNA-seq studies. Is affected by four chemicals including multi-walled carbon nanotube; Sirolimus; and rifampin based on RNA-seq studies.

Y54G2A.57

Caenorhabditis elegans

Enriched in intestine; neurons; and in male based on RNA-seq studies. Is affected by several genes including exc-7; nuo-6; and wrn-1 based on microarray and RNA-seq studies. Is affected by six chemicals including Psoralens; allantoin; and Sirolimus based on RNA-seq studies.

clec-228

Caenorhabditis elegans

Enriched in dopaminergic neurons based on tiling array studies. Is affected by several genes including rsr-2; wrn-1; and drh-3 based on tiling array; microarray; and RNA-seq studies. Is affected by six chemicals including metformin; Sirolimus; and rifampin based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domains: C-type lectin-like/link domain superfamily; C-type lectin-like; and C-type lectin fold.

R08E5.4

Caenorhabditis elegans

Enriched in AWCL; amphid sheath cell; body wall muscle cell; dopaminergic neurons; and hypodermis based on tiling array; RNA-seq; and single-cell RNA-seq studies. Is affected by several genes including wrn-1; dpy-21; and hpl-2 based on microarray and RNA-seq studies. Is affected by eight chemicals including Tunicamycin; multi-walled carbon nanotube; and leptomycin B based on microarray and RNA-seq studies. Is predicted to encode a protein with the following domain: Phosphorylation site.