cwn-2

Caenorhabditis elegans

Predicted to enable cytokine activity and frizzled binding activity. Involved in several processes, including neuroblast migration; neuron migration; and pattern specification process. Predicted to be located in extracellular space. Expressed in several structures, including P5.ppp; P7.paa; RME; pharynx; and rectal gland cell. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant Robinow syndrome 1; endometrial carcinoma; and germ cell cancer (multiple). Is an ortholog of human WNT5A (Wnt family member 5A) and WNT5B (Wnt family member 5B).

cfz-2

Caenorhabditis elegans

Predicted to enable Wnt receptor activity and Wnt-protein binding activity. Involved in neuroblast migration; neuron migration; and positive regulation of motor neuron migration. Predicted to be located in plasma membrane. Expressed in intestine; nervous system; and pharynx. Is an ortholog of human FZD5 (frizzled class receptor 5).

pygo-1

Caenorhabditis elegans

Predicted to be involved in Wnt signaling pathway. Predicted to be located in nucleus. Is an ortholog of human PYGO1 (pygopus family PHD finger 1) and PYGO2 (pygopus family PHD finger 2).

mom-1

Caenorhabditis elegans

Predicted to enable Wnt-protein binding activity and palmitoleoyltransferase activity. Involved in several processes, including Wnt signaling pathway, regulating spindle positioning; asymmetric protein localization involved in cell fate determination; and embryonic morphogenesis. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in focal dermal hypoplasia. Is an ortholog of human PORCN (porcupine O-acyltransferase).

sfrp-1

Caenorhabditis elegans

Predicted to enable Wnt-protein binding activity. Predicted to be involved in canonical Wnt signaling pathway and non-canonical Wnt signaling pathway. Located in nucleus. Expressed in head muscle and ventral cord neurons. Human ortholog(s) of this gene implicated in in situ carcinoma; leiomyoma; and renal cell carcinoma. Is an ortholog of human SFRP1 (secreted frizzled related protein 1).

dsh-1

Caenorhabditis elegans

Enables receptor tyrosine kinase binding activity. Involved in Wnt signaling pathway, regulating spindle positioning. Predicted to be located in cytosol. Expressed in several structures, including germ line; gonad; neurons; tail; and vulva. Human ortholog(s) of this gene implicated in DiGeorge syndrome and autosomal dominant Robinow syndrome 2. Is an ortholog of human DVL1 (dishevelled segment polarity protein 1).

mig-5

Caenorhabditis elegans

Predicted to enable frizzled binding activity. Involved in several processes, including cell differentiation; inductive cell migration; and non-canonical Wnt signaling pathway. Located in cell cortex. Expressed in several structures, including distal tip cell; linker cell; nerve ring; posterior lateral left ganglion; and somatic gonad precursor. Human ortholog(s) of this gene implicated in DiGeorge syndrome; Robinow syndrome (multiple); and lung cancer. Is an ortholog of human DVL1 (dishevelled segment polarity protein 1); DVL2 (dishevelled segment polarity protein 2); and DVL3 (dishevelled segment polarity protein 3).

apr-1

Caenorhabditis elegans

Enables beta-catenin binding activity. Involved in several processes, including embryonic morphogenesis; regulation of Wnt signaling pathway; and regulation of multicellular organismal development. Located in adherens junction; cell cortex; and nucleus. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P8.p hermaphrodite; distal tip cell; and excretory cell. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Sotos syndrome 3; carcinoma (multiple); and gastrointestinal system cancer (multiple). Is an ortholog of human APC (APC regulator of WNT signaling pathway) and APC2 (APC regulator of WNT signaling pathway 2).

dsh-2

Caenorhabditis elegans

Predicted to enable frizzled binding activity. Involved in several processes, including Wnt signaling pathway, regulating spindle positioning; embryonic morphogenesis; and left/right axis specification. Located in cell cortex. Expressed in several structures, including QL; QR; distal tip cell; midbody; and somatic gonad precursor. Human ortholog(s) of this gene implicated in DiGeorge syndrome; Robinow syndrome (multiple); and lung cancer. Is an ortholog of human DVL1 (dishevelled segment polarity protein 1).

mig-14

Caenorhabditis elegans

Predicted to enable Wnt-protein binding activity. Involved in several processes, including Wnt signaling pathway; embryonic morphogenesis; and left/right axis specification. Located in basolateral plasma membrane and cytoplasmic vesicle. Expressed in several structures, including CAN; anal region; intestinal muscle; tail hypodermis; and ventral nerve cord. Human ortholog(s) of this gene implicated in Zaki syndrome. Is an ortholog of human WLS (Wnt ligand secretion mediator).