vps-54

Caenorhabditis elegans

Enables syntaxin binding activity. Predicted to be involved in Golgi to vacuole transport and retrograde transport, endosome to Golgi. Part of GARP complex. Expressed in body wall musculature. Is an ortholog of human VPS54 (VPS54 subunit of GARP complex).

vps-52

Caenorhabditis elegans

Enables small GTPase binding activity and syntaxin binding activity. Involved in negative regulation of dense core granule transport; positive regulation of dense core granule transport; and positive regulation of locomotion involved in locomotory behavior. Located in Golgi cisterna; perikaryon; and perinuclear region of cytoplasm. Part of GARP complex. Expressed in distal tip cell; neurons; somatic cell; and somatic gonad. Is an ortholog of human VPS52 (VPS52 subunit of GARP complex).

vps-53

Caenorhabditis elegans

Involved in positive regulation of locomotion involved in locomotory behavior; regulation of brood size; and regulation of dense core granule transport. Located in perikaryon and perinuclear region of cytoplasm. Part of GARP complex. Expressed in body wall musculature; intestine; and pharynx. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2E. Is an ortholog of human VPS53 (VPS53 subunit of GARP complex).

vps-51

Caenorhabditis elegans

Enables syntaxin binding activity. Involved in negative regulation of dense core granule transport; positive regulation of dense core granule transport; and positive regulation of locomotion involved in locomotory behavior. Part of GARP complex. Expressed in body wall musculature; intestinal cell; and neurons. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 13. Is an ortholog of human VPS51 (VPS51 subunit of GARP complex).

vps-28

Caenorhabditis elegans

Involved in receptor catabolic process. Part of ESCRT I complex. Is an ortholog of human VPS28 (VPS28 subunit of ESCRT-I).

vps-37

Caenorhabditis elegans

Involved in receptor catabolic process. Located in cytosol and endosome membrane. Part of ESCRT I complex. Expressed in head and tail. Is an ortholog of human VPS37B (VPS37B subunit of ESCRT-I).

vps-16

Caenorhabditis elegans

Predicted to enable actin binding activity. Involved in digestive tract development and embryo development. Predicted to be located in endosome. Predicted to be part of HOPS complex. Human ortholog(s) of this gene implicated in dystonia. Is an ortholog of human VPS16 (VPS16 core subunit of CORVET and HOPS complexes).

vps-18

Caenorhabditis elegans

Predicted to enable protein-macromolecule adaptor activity. Involved in endosome organization and phagosome-lysosome fusion involved in apoptotic cell clearance. Located in cytoplasm. Expressed in body wall musculature; coelomocyte; hermaphrodite gonad; hypodermis; and intestine. Is an ortholog of human VPS18 (VPS18 core subunit of CORVET and HOPS complexes).

vps-41

Caenorhabditis elegans

Predicted to enable metal ion binding activity. Involved in negative regulation of apoptotic process; vacuolar protein processing; and vacuolar transport. Predicted to be located in late endosome. Predicted to be part of HOPS complex. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 29. Is an ortholog of human VPS41 (VPS41 subunit of HOPS complex).

vps-34

Caenorhabditis elegans

Enables 1-phosphatidylinositol-3-kinase activity. Involved in several processes, including determination of adult lifespan; ecdysis, collagen and cuticulin-based cuticle; and regulation of transport. Located in cytoplasm; nuclear outer membrane; and nucleolus. Is an ortholog of human PIK3C3 (phosphatidylinositol 3-kinase catalytic subunit type 3).