hgrs-1

Caenorhabditis elegans

Enables ubiquitin binding activity. Involved in protein localization to non-motile cilium. Located in early endosome and endosome membrane. Part of ESCRT-0 complex. Expressed in several structures, including coelomocyte; excretory canal; hermaphrodite gonad; intestine; and vulva. Is an ortholog of human HGS (hepatocyte growth factor-regulated tyrosine kinase substrate).

vps-54

Caenorhabditis elegans

Enables syntaxin binding activity. Predicted to be involved in Golgi to vacuole transport and retrograde transport, endosome to Golgi. Part of GARP complex. Expressed in body wall musculature. Is an ortholog of human VPS54 (VPS54 subunit of GARP complex).

vps-52

Caenorhabditis elegans

Enables small GTPase binding activity and syntaxin binding activity. Involved in negative regulation of dense core granule transport; positive regulation of dense core granule transport; and positive regulation of locomotion involved in locomotory behavior. Located in Golgi cisterna; perikaryon; and perinuclear region of cytoplasm. Part of GARP complex. Expressed in distal tip cell; neurons; somatic cell; and somatic gonad. Is an ortholog of human VPS52 (VPS52 subunit of GARP complex).

vps-53

Caenorhabditis elegans

Involved in positive regulation of locomotion involved in locomotory behavior; regulation of brood size; and regulation of dense core granule transport. Located in perikaryon and perinuclear region of cytoplasm. Part of GARP complex. Expressed in body wall musculature; intestine; and pharynx. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2E. Is an ortholog of human VPS53 (VPS53 subunit of GARP complex).

vps-51

Caenorhabditis elegans

Enables syntaxin binding activity. Involved in negative regulation of dense core granule transport; positive regulation of dense core granule transport; and positive regulation of locomotion involved in locomotory behavior. Part of GARP complex. Expressed in body wall musculature; intestinal cell; and neurons. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 13. Is an ortholog of human VPS51 (VPS51 subunit of GARP complex).

Y51H4A.27

Caenorhabditis elegans

lin-27

Caenorhabditis elegans

vps-28

Caenorhabditis elegans

Involved in receptor catabolic process. Part of ESCRT I complex. Is an ortholog of human VPS28 (VPS28 subunit of ESCRT-I).

dpy-27

Caenorhabditis elegans

Enables sequence-specific DNA binding activity. Involved in dosage compensation by hypoactivation of X chromosome. Located in X chromosome and nuclear chromosome. Part of dosage compensation complex. Is an ortholog of human SMC4 (structural maintenance of chromosomes 4).

vps-37

Caenorhabditis elegans

Involved in receptor catabolic process. Located in cytosol and endosome membrane. Part of ESCRT I complex. Expressed in head and tail. Is an ortholog of human VPS37B (VPS37B subunit of ESCRT-I).