vhl-1

Caenorhabditis elegans

Involved in response to hypoxia. Part of Cul2-RING ubiquitin ligase complex. Expressed in several structures, including ADFL and ADFR. Used to study clear cell renal cell carcinoma and von Hippel-Lindau disease. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); familial erythrocytosis 2; and von Hippel-Lindau disease. Is an ortholog of human VHL (von Hippel-Lindau tumor suppressor).

clec-59

Caenorhabditis elegans

Is affected by several genes including rsr-2; hsf-1; and wrn-1 based on tiling array; RNA-seq; and microarray studies. Is affected by seven chemicals including Psoralens; allantoin; and Sirolimus based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domains: von Willebrand factor type A domain; C-type lectin-like/link domain superfamily; von Willebrand factor A-like domain superfamily; von Willebrand factor, type A; C-type lectin-like; and C-type lectin fold.

H13N06.2

Caenorhabditis elegans

Enriched in anchor cell; epithelial cell; germline precursor cell; and hypodermis based on tiling array; single-cell RNA-seq; and RNA-seq studies. Is affected by several genes including cyc-1; swsn-1; and nuo-6 based on microarray and RNA-seq studies. Is affected by ten chemicals including D-glucose; stavudine; and Zidovudine based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domains: von Willebrand factor, type A; von Willebrand factor type A domain; von Willebrand factor A-like domain superfamily; and Extracellular Matrix Assembly and Organization.

K09E2.1

Caenorhabditis elegans

Enriched in FLP; hypodermis; and neurons based on RNA-seq and single-cell RNA-seq studies. Is affected by several genes including csr-1; prg-1; and wrn-1 based on RNA-seq and microarray studies. Is affected by four chemicals including sucrose; stearic acid; and single-walled carbon nanotube based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domains: Collagen VI and Biomineralization Protein PIF; von Willebrand factor, type A; von Willebrand factor type A domain; and von Willebrand factor A-like domain superfamily.

clec-58

Caenorhabditis elegans

Enriched in NSM based on tiling array studies. Is affected by several genes including atf-7; drh-3; and spt-16 based on RNA-seq studies. Is affected by eight chemicals including methylmercuric chloride; Tunicamycin; and rifampin based on microarray and RNA-seq studies. Is predicted to encode a protein with the following domains: von Willebrand factor type A domain; C-type lectin-like/link domain superfamily; von Willebrand factor A-like domain superfamily; von Willebrand factor, type A; C-type lectin-like; and C-type lectin fold.

clec-163

Caenorhabditis elegans

Is affected by several genes including cyc-1; atf-7; and ztf-11 based on microarray; RNA-seq; and tiling array studies. Is affected by six chemicals including Mercuric Chloride; Tunicamycin; and tert-Butylhydroperoxide based on microarray and RNA-seq studies. Is predicted to encode a protein with the following domains: von Willebrand factor type A domain; C-type lectin fold; C-type lectin-like/link domain superfamily; Lectin C-type domain; von Willebrand factor A-like domain superfamily; von Willebrand factor, type A; C-type lectin-like; and Phosphorylation site.

C24B9.3

Caenorhabditis elegans

Enriched in AWCL; germ line; head mesodermal cell; intestinal cell; and intestine based on tiling array; RNA-seq; and single-cell RNA-seq studies. Is affected by several genes including ptl-1; etr-1; and hsf-1 based on microarray; proteomic; and RNA-seq studies. Is affected by twenty-one chemicals including methylmercuric chloride; stavudine; and Psoralens based on microarray and RNA-seq studies. Is predicted to encode a protein with the following domains: von Willebrand factor, type A; von Willebrand factor type A domain; von Willebrand factor A-like domain superfamily; and Extracellular Matrix Assembly and Organization.

T13G4.4

Caenorhabditis elegans

Predicted to enable S-adenosylmethionine-homocysteine S-methyltransferase activity. Predicted to be involved in S-methylmethionine cycle and methionine biosynthetic process.

C29A12.6

Caenorhabditis elegans

Enriched in hypodermis; intestine; neurons; seam cell; and sensory neurons based on tiling array; RNA-seq; and single-cell RNA-seq studies. Is affected by several genes including numr-2; numr-1; and mter-4 based on tiling array; microarray; and RNA-seq studies. Is affected by seventeen chemicals including methylmercuric chloride; rotenone; and stavudine based on microarray and RNA-seq studies. Is predicted to encode a protein with the following domains: Collagen VI and Biomineralization Protein PIF; von Willebrand factor, type A; von Willebrand factor type A domain; and von Willebrand factor A-like domain superfamily.

clec-143

Caenorhabditis elegans

Enriched in intestine and sensory neurons based on RNA-seq studies. Is affected by several genes including swsn-2.2; nuo-6; and atfs-1 based on microarray; RNA-seq; and tiling array studies. Is affected by twenty-two chemicals including 1-methylnicotinamide; methylmercuric chloride; and Tunicamycin based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domains: von Willebrand factor type A domain; C-type lectin-like/link domain superfamily; von Willebrand factor A-like domain superfamily; von Willebrand factor, type A; C-type lectin-like; and C-type lectin fold.