Enables troponin C binding activity. Involved in locomotion and sarcomere organization. Located in sarcomere. Expressed in body wall musculature; non-striated muscle; and rectal muscle. Human ortholog(s) of this gene implicated in several diseases, including arthrogryposis multiplex congenita; distal arthrogryposis type 2B1; and intrinsic cardiomyopathy (multiple). Is an ortholog of human TNNI1 (troponin I1, slow skeletal type); TNNI2 (troponin I2, fast skeletal type); and TNNI3 (troponin I3, cardiac type).
Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in protein deubiquitination. Predicted to be located in cytosol and nucleus. Human ortholog(s) of this gene implicated in Y-linked spermatogenic failure 2; female-restricted syndromic X-linked intellectual disability 99; and non-syndromic X-linked intellectual disability 99. Is an ortholog of human USP24 (ubiquitin specific peptidase 24).
Involved in dopaminergic neuron differentiation. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 99. Is an ortholog of human TMEM132B (transmembrane protein 132B).
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in brain development; neuron differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus.
Enables myosin binding activity. Involved in locomotion; regulation of cytoskeleton organization; and striated muscle myosin thick filament assembly. Located in M band and striated muscle myosin thick filament. Expressed in anal depressor muscle; body wall musculature; and pharyngeal muscle cell.
Involved in regulation of axon extension and regulation of synapse organization. Located in axon; neuronal cell body; and perinuclear region of cytoplasm. Expressed in CAN; HSN; ganglia; somatic nervous system; and touch receptor neurons. Is an ortholog of human SCOC (short coiled-coil protein).