unc-97

Caenorhabditis elegans

Enables myosin binding activity. Involved in several processes, including muscle cell cellular homeostasis; positive regulation of sarcomere organization; and sensory perception of mechanical stimulus. Located in several cellular components, including adherens junction; basal plasma membrane; and contractile muscle fiber. Expressed in body wall musculature and vulval muscle. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2W. Is an ortholog of human LIMS1 (LIM zinc finger domain containing 1) and LIMS2 (LIM zinc finger domain containing 2).

F46F11.7

Caenorhabditis elegans

Enriched in several structures, including ABarpaapap; ABarpaappa; ABarpaappp; ABarppaapa; and germ line based on RNA-seq and single-cell RNA-seq studies. Is affected by several genes including cyc-1; nuo-6; and numr-2 based on microarray; tiling array; and RNA-seq studies. Is affected by eleven chemicals including rotenone; Alovudine; and stavudine based on RNA-seq and microarray studies.

unc-98

Caenorhabditis elegans

Enables cytoskeletal protein binding activity. Involved in several processes, including locomotory behavior; myofibril assembly; and post-embryonic body morphogenesis. Located in M band and nucleus. Expressed in anal depressor muscle; body wall musculature; head muscle; and vulval muscle.

pin-2

Caenorhabditis elegans

Predicted to enable metal ion binding activity. Predicted to be involved in several processes, including cell-cell junction organization; positive regulation of integrin-mediated signaling pathway; and positive regulation of substrate adhesion-dependent cell spreading. Located in cytoplasm; nucleus; and varicosity. Expressed in PVT.

seu-2

Caenorhabditis elegans

Acts upstream of or within dorsal/ventral axon guidance.

seu-3

Caenorhabditis elegans

Acts upstream of or within dorsal/ventral axon guidance.

lim-9

Caenorhabditis elegans

Enables protein domain specific binding activity. Located in M band. Expressed in several structures, including body wall musculature; excretory canal; non-striated muscle; spermatheca; and vulva. Is an ortholog of human FHL2 (four and a half LIM domains 2).

lim-8

Caenorhabditis elegans

Enables protein domain specific binding activity. Predicted to be involved in positive regulation of stress fiber assembly and regulation of focal adhesion assembly. Located in M band. Expressed in excretory canal; head neurons; non-striated muscle; spermatheca; and vulva. Is an ortholog of human LIMCH1 (LIM and calponin homology domains 1).

unc-96

Caenorhabditis elegans

Enables myosin binding activity. Involved in locomotion; regulation of cytoskeleton organization; and striated muscle myosin thick filament assembly. Located in M band and striated muscle myosin thick filament. Expressed in anal depressor muscle; body wall musculature; and pharyngeal muscle cell.

F07A11.12

Caenorhabditis elegans

Is affected by several genes including hpl-2; unc-39; and unc-30 based on RNA-seq studies.