Enables cohesin loader activity. Involved in several processes, including chromosome organization; double-strand break repair involved in meiotic recombination; and regulation of cell cycle process. Located in chromosome and nucleus. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 1. Is an ortholog of human NIPBL (NIPBL cohesin loading factor).
Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Predicted to be involved in cell differentiation; hormone-mediated signaling pathway; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in excretory duct cell; hypodermis; vulva; and vulval precursor cell. Human ortholog(s) of this gene implicated in several diseases, including alcoholic liver cirrhosis; brain small vessel disease; and type 2 diabetes mellitus. Is an ortholog of human NR1D1 (nuclear receptor subfamily 1 group D member 1) and NR1D2 (nuclear receptor subfamily 1 group D member 2).
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in mechanosensory behavior; neuron differentiation; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Expressed in neurons. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 15. Is an ortholog of human POU4F1 (POU class 4 homeobox 1); POU4F2 (POU class 4 homeobox 2); and POU4F3 (POU class 4 homeobox 3).
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and transcription corepressor activity. Involved in several processes, including negative regulation of canonical Wnt signaling pathway; negative regulation of transcription by RNA polymerase II; and regulation of cellular component organization. Located in nucleus. Expressed in several structures, including germ line; head; and tail. Is an ortholog of human TLE2 (TLE family member 2, transcriptional corepressor).
Predicted to enable protein dimerization activity. Predicted to contribute to RNA polymerase II activity. Predicted to be involved in transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II, core complex. Is an ortholog of human POLR2J (RNA polymerase II subunit J); POLR2J2 (RNA polymerase II subunit J2); and POLR2J3 (RNA polymerase II subunit J3).