Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in several processes, including generation of neurons; modulation of chemical synaptic transmission; and regulation of neuron projection development. Located in axon; cytoplasm; and muscle cell projection. Expressed in several structures, including egg-laying apparatus; hermaphrodite gonad; lumbar ganglion; neurons; and tail hypodermis. Used to study epilepsy. Human ortholog(s) of this gene implicated in artery disease (multiple); autosomal dominant intellectual developmental disorder 44; and cerebral infarction. Is an ortholog of human KALRN (kalirin RhoGEF kinase) and TRIO (trio Rho guanine nucleotide exchange factor).
Enables protein homodimerization activity; signaling receptor binding activity; and ubiquitin-protein transferase activity. Involved in cell projection organization; protein ubiquitination; and regulation of protein localization. Located in several cellular components, including cell leading edge; neuronal cell body; and striated muscle dense body. Expressed in several structures, including anchor cell; intestinal cell; muscle cell; neurons; and ray precursor cell. Used to study Opitz GBBB syndrome. Human ortholog(s) of this gene implicated in Opitz GBBB syndrome; anencephaly; and non-syndromic X-linked intellectual disability 101. Is an ortholog of human TRIM67 (tripartite motif containing 67) and TRIM9 (tripartite motif containing 9).
Is affected by several genes including prg-1; glp-4; and alg-1 based on tiling array and RNA-seq studies. Is affected by multi-walled carbon nanotube and graphene oxide based on RNA-seq studies.
Predicted to enable RNA polymerase II complex binding activity. Predicted to be involved in positive regulation of transcription elongation by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of Cdc73/Paf1 complex. Human ortholog(s) of this gene implicated in carcinoma (multiple); colorectal cancer; and hyperparathyroidism. Is an ortholog of human CDC73 (cell division cycle 73).