Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Involved in cell fate specification; negative regulation of transcription by RNA polymerase II; and neuron remodeling. Predicted to be located in nucleus. Expressed in motor neurons; somatic nervous system; and spicule muscle. Human ortholog(s) of this gene implicated in 46,XX sex reversal 5 and Bosch-Boonstra-Schaaf optic atrophy syndrome. Is an ortholog of human NR2F1 (nuclear receptor subfamily 2 group F member 1) and NR2F2 (nuclear receptor subfamily 2 group F member 2).
Enables chloride channel activity. Involved in chloride transport and mechanosensory behavior. Located in neuronal cell body and postsynaptic density. Expressed in GLR; egg-laying apparatus; head muscle; nerve ring; and neurons.
Predicted to enable mRNA binding activity. Involved in inductive cell migration and nematode larval development. Located in cytoplasm and nucleus. Expressed in gonad; hypodermis; muscle cell; and vulva. Is an ortholog of human NSRP1 (nuclear speckle splicing regulatory protein 1).
Predicted to enable clathrin adaptor activity. Involved in positive regulation of locomotion. Located in synapse. Expressed in DD neuron; VD neuron; and cholinergic neurons. Is an ortholog of human STON2 (stonin 2).
Enables protein kinase binding activity and scaffold protein binding activity. Involved in regulation of protein localization and synaptic vesicle localization. Located in neuron projection. Expressed in several structures, including hypodermis; intestine; motor neurons; muscle cell; and uterus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 61. Is an ortholog of human RUSC1 (RUN and SH3 domain containing 1) and RUSC2 (RUN and SH3 domain containing 2).