unc-43

Caenorhabditis elegans

Enables calcium/calmodulin-dependent protein kinase activity; identical protein binding activity; and transmembrane transporter binding activity. Involved in MAPK cascade; medium-term memory; and positive regulation of gene expression. Acts upstream of or within serotonin biosynthetic process. Located in axon cytoplasm. Expressed in several structures, including AWC; copulatory spicule; gonadal sheath cell; oocyte; and somatic nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease; intellectual disability (multiple); and malignant astrocytoma. Is an ortholog of human CAMK2D (calcium/calmodulin dependent protein kinase II delta).

ham-2

Caenorhabditis elegans

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in cell fate determination; cell migration; and regulation of neuron differentiation. Located in nucleus.

eif-1

Caenorhabditis elegans

Predicted to enable RNA binding activity; ribosomal small subunit binding activity; and translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to be part of eukaryotic 43S preinitiation complex. Expressed in head and tail. Is an ortholog of human EIF1B (eukaryotic translation initiation factor 1B).

egl-2

Caenorhabditis elegans

Enables protein kinase binding activity. Involved in chemosensory behavior; egg-laying behavior; and muscle contraction. Located in microvillus membrane. Expressed in several structures, including intestinal cell; lumbar neurons; sensory neurons; vulval muscle; and in male. Human ortholog(s) of this gene implicated in carcinoma (multiple) and developmental and epileptic encephalopathy. Is an ortholog of human KCNH5 (potassium voltage-gated channel subfamily H member 5).

seu-2

Caenorhabditis elegans

Acts upstream of or within dorsal/ventral axon guidance.

seu-3

Caenorhabditis elegans

Acts upstream of or within dorsal/ventral axon guidance.

nsy-1

Caenorhabditis elegans

Enables MAP kinase kinase kinase activity; mitogen-activated protein kinase kinase binding activity; and protein serine/threonine/tyrosine kinase activity. Involved in several processes, including determination of adult lifespan; positive regulation of macromolecule biosynthetic process; and response to stress. Located in axon cytoplasm; neuronal cell body; and postsynaptic density. Expressed in head; rectal gland cell; and tail. Used to study amphetamine abuse. Human ortholog(s) of this gene implicated in Huntington's disease and perinatal necrotizing enterocolitis. Is an ortholog of human MAP3K5 (mitogen-activated protein kinase kinase kinase 5).

tir-1

Caenorhabditis elegans

Enables several functions, including NAD+ nucleosidase activity; enzyme binding activity; and identical protein binding activity. Involved in several processes, including NAD catabolic process; defense response to other organism; and regulation of gene expression. Acts upstream of or within serotonin biosynthetic process. Located in axon cytoplasm and cell body. Expressed in head. Used to study amyotrophic lateral sclerosis. Is an ortholog of human SARM1 (sterile alpha and TIR motif containing 1).

eif-3.H

Caenorhabditis elegans

Predicted to enable metallopeptidase activity. Predicted to contribute to translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic 43S preinitiation complex and eukaryotic translation initiation factor 3 complex. Human ortholog(s) of this gene implicated in breast cancer and prostate carcinoma. Is an ortholog of human EIF3H (eukaryotic translation initiation factor 3 subunit H).

unc-96

Caenorhabditis elegans

Enables myosin binding activity. Involved in locomotion; regulation of cytoskeleton organization; and striated muscle myosin thick filament assembly. Located in M band and striated muscle myosin thick filament. Expressed in anal depressor muscle; body wall musculature; and pharyngeal muscle cell.