Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in animal organ development; neuron development; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in dopaminergic neurons.
Enables netrin receptor activity and protein domain specific binding activity. Involved in several processes, including axon guidance; regulation of locomotion; and sex differentiation. Acts upstream of or within dendrite morphogenesis and distal tip cell migration. Located in axonal growth cone and cell projection membrane. Part of receptor complex. Expressed in several structures, including hermaphrodite somatic gonadal cell; motor neurons; neuroblasts; somatic nervous system; and touch receptor neurons. Human ortholog(s) of this gene implicated in colorectal cancer; congenital mirror movement disorder; and esophagus squamous cell carcinoma. Is an ortholog of human DCC (DCC netrin 1 receptor) and NEO1 (neogenin 1).
Enables protein homodimerization activity; signaling receptor binding activity; and ubiquitin-protein transferase activity. Involved in cell projection organization; protein ubiquitination; and regulation of protein localization. Located in several cellular components, including cell leading edge; neuronal cell body; and striated muscle dense body. Expressed in several structures, including anchor cell; intestinal cell; muscle cell; neurons; and ray precursor cell. Used to study Opitz GBBB syndrome. Human ortholog(s) of this gene implicated in Opitz GBBB syndrome; anencephaly; and non-syndromic X-linked intellectual disability 101. Is an ortholog of human TRIM67 (tripartite motif containing 67) and TRIM9 (tripartite motif containing 9).
Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Involved in cell fate specification; negative regulation of transcription by RNA polymerase II; and neuron remodeling. Predicted to be located in nucleus. Expressed in motor neurons; somatic nervous system; and spicule muscle. Human ortholog(s) of this gene implicated in 46,XX sex reversal 5 and Bosch-Boonstra-Schaaf optic atrophy syndrome. Is an ortholog of human NR2F1 (nuclear receptor subfamily 2 group F member 1) and NR2F2 (nuclear receptor subfamily 2 group F member 2).
Predicted to enable clathrin adaptor activity. Involved in positive regulation of locomotion. Located in synapse. Expressed in DD neuron; VD neuron; and cholinergic neurons. Is an ortholog of human STON2 (stonin 2).