rax-4

Caenorhabditis elegans

mig-21

Caenorhabditis elegans

Predicted to enable signaling receptor activity. Involved in several processes, including cell migration; determination of left/right asymmetry in nervous system; and regulation of canonical Wnt signaling pathway. Predicted to be located in plasma membrane. Expressed in QL; QR; and body wall musculature.

unc-40

Caenorhabditis elegans

Enables netrin receptor activity and protein domain specific binding activity. Involved in several processes, including axon guidance; regulation of locomotion; and sex differentiation. Acts upstream of or within dendrite morphogenesis and distal tip cell migration. Located in axonal growth cone and cell projection membrane. Part of receptor complex. Expressed in several structures, including hermaphrodite somatic gonadal cell; motor neurons; neuroblasts; somatic nervous system; and touch receptor neurons. Human ortholog(s) of this gene implicated in colorectal cancer; congenital mirror movement disorder; and esophagus squamous cell carcinoma. Is an ortholog of human DCC (DCC netrin 1 receptor) and NEO1 (neogenin 1).

madd-2

Caenorhabditis elegans

Enables protein homodimerization activity; signaling receptor binding activity; and ubiquitin-protein transferase activity. Involved in cell projection organization; protein ubiquitination; and regulation of protein localization. Located in several cellular components, including cell leading edge; neuronal cell body; and striated muscle dense body. Expressed in several structures, including anchor cell; intestinal cell; muscle cell; neurons; and ray precursor cell. Used to study Opitz GBBB syndrome. Human ortholog(s) of this gene implicated in Opitz GBBB syndrome; anencephaly; and non-syndromic X-linked intellectual disability 101. Is an ortholog of human TRIM67 (tripartite motif containing 67) and TRIM9 (tripartite motif containing 9).

unc-34

Caenorhabditis elegans

Enables signaling receptor binding activity. Involved in axon development; gonad morphogenesis; and positive regulation of locomotion. Located in several cellular components, including cell junction; cell leading edge; and filopodium tip. Expressed in epithelial cell. Used to study tauopathy. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Is an ortholog of human ENAH (ENAH actin regulator) and EVL (Enah/Vasp-like).

seu-2

Caenorhabditis elegans

Acts upstream of or within dorsal/ventral axon guidance.

seu-3

Caenorhabditis elegans

Acts upstream of or within dorsal/ventral axon guidance.

pvf-1

Caenorhabditis elegans

Predicted to enable growth factor receptor binding activity. Involved in negative regulation of netrin-activated signaling pathway and nematode male tail tip morphogenesis. Predicted to be located in extracellular space. Expressed in body wall musculature. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; central nervous system cancer (multiple); diabetic retinopathy (multiple); and reproductive organ cancer (multiple). Is an ortholog of human PDGFA (platelet derived growth factor subunit A) and PDGFB (platelet derived growth factor subunit B).

ceh-40

Caenorhabditis elegans

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in animal organ development; neuron development; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in dopaminergic neurons.

let-40

Caenorhabditis elegans