unc-86

Caenorhabditis elegans

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in mechanosensory behavior; neuron differentiation; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Expressed in neurons. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 15. Is an ortholog of human POU4F1 (POU class 4 homeobox 1); POU4F2 (POU class 4 homeobox 2); and POU4F3 (POU class 4 homeobox 3).

linc-67

Caenorhabditis elegans

Is affected by several genes including ints-4; unc-30; and alh-4 based on RNA-seq studies.

unc-4

Caenorhabditis elegans

Enables DNA-binding transcription factor activity. Involved in several processes, including negative regulation of canonical Wnt signaling pathway; nervous system development; and regulation of cellular component organization. Located in axon and nucleus. Expressed in I5 neuron; cholinergic neurons; and somatic nervous system.

aptf-4

Caenorhabditis elegans

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II and regulation of cell population proliferation. Predicted to be located in nucleus. Expressed in head neurons and ventral nerve cord.

mel-4

Caenorhabditis elegans

Acts upstream of or within embryo development.

fkh-4

Caenorhabditis elegans

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Located in nucleus.

inpp-4B

Caenorhabditis elegans

Predicted to enable phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity. Predicted to be involved in phosphatidylinositol-3-phosphate biosynthetic process. Predicted to be located in cytoplasm. Is an ortholog of human INPP4B (inositol polyphosphate-4-phosphatase type II B).

rax-4

Caenorhabditis elegans

unc-17

Caenorhabditis elegans

Enables acetylcholine transmembrane transporter activity. Involved in several processes, including cholinergic synaptic transmission; nematode larval development; and regulation of nematode pharyngeal pumping. Located in neuron projection; organelle membrane; and synapse. Expressed in neurons; pm2; somatic nervous system; and in male. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; and congenital myasthenic syndrome 21. Is an ortholog of human SLC18A3 (solute carrier family 18 member A3).

W02D3.12

Caenorhabditis elegans

Predicted to be involved in mitochondrial respiratory chain complex II assembly. Predicted to be located in mitochondrion. Is an ortholog of human SDHAF4 (succinate dehydrogenase complex assembly factor 4).