lev-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables acetylcholine receptor activity and acetylcholine-gated monoatomic cation-selective channel activity. Involved in regulation of egg-laying behavior; regulation of locomotion; and transmembrane transport. Located in neuron projection; neuronal cell body; and postsynaptic membrane. Expressed in body wall musculature; dorsal nerve cord; nerve ring; ventral cord neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including congenital myasthenic syndrome (multiple); lung disease (multiple); and nicotine dependence. Is an ortholog of human CHRNA1 (cholinergic receptor nicotinic alpha 1 subunit); CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit); and CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit).
unc-29 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables acetylcholine-gated monoatomic cation-selective channel activity. Involved in several processes, including neuromuscular synaptic transmission; positive regulation of acetylcholine secretion, neurotransmission; and regulation of multicellular organismal process. Located in neuron projection; neuronal cell body; and postsynaptic membrane. Expressed in body wall musculature; head neurons; non-striated muscle; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Lewy body dementia; autosomal dominant nocturnal frontal lobe epilepsy 1; and congenital myasthenic syndrome (multiple). Is an ortholog of human CHRNA1 (cholinergic receptor nicotinic alpha 1 subunit); CHRNA4 (cholinergic receptor nicotinic alpha 4 subunit); and CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit).
snap-29 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable SNAP receptor activity and syntaxin binding activity. Involved in intracellular protein transmembrane transport; ovulation; and secretion. Located in apical plasma membrane and recycling endosome. Expressed in several structures, including coelomocyte; excretory canal; gland cell; hermaphrodite somatic gonadal cell; and vulva. Used to study chromosome 22q11.2 deletion syndrome, distal. Human ortholog(s) of this gene implicated in CEDNIK syndrome. Is an ortholog of human SNAP29 (synaptosome associated protein 29).