ttx-7

Caenorhabditis elegans

Predicted to enable inositol monophosphate 1-phosphatase activity and metal ion binding activity. Involved in chemotaxis; protein localization to synapse; and thermotaxis. Located in cytoplasm. Expressed in several structures, including coelomocyte; gonad; intestine; neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 59; bipolar disorder; and schizophrenia. Is an ortholog of human IMPA1 (inositol monophosphatase 1) and IMPA2 (inositol monophosphatase 2).

ttx-1

Caenorhabditis elegans

Enables DNA-binding transcription factor activity and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including positive regulation of transcription by RNA polymerase II; regulation of plasma membrane bounded cell projection assembly; and thermosensory behavior. Located in nucleus. Expressed in head neurons and pharyngeal cell. Human ortholog(s) of this gene implicated in panhypopituitarism and syndromic microphthalmia 5. Is an ortholog of human OTX1 (orthodenticle homeobox 1).

mau-6

Caenorhabditis elegans

let-6

Caenorhabditis elegans

Acts upstream of or within nematode larval development.

amo-6

Caenorhabditis elegans

cps-6

Caenorhabditis elegans

Enables endonuclease activity; protein homodimerization activity; and sequence-specific DNA binding activity. Involved in RNA catabolic process and apoptotic DNA fragmentation. Located in mitochondrial intermembrane space. Is an ortholog of human ENDOG (endonuclease G).

Y57G11C.3

Caenorhabditis elegans

Predicted to enable 6-phosphogluconolactonase activity. Predicted to be involved in pentose-phosphate shunt, oxidative branch. Located in nucleus. Expressed in germ cell. Is an ortholog of human PGLS (6-phosphogluconolactonase).

glb-6

Caenorhabditis elegans

Enables heme binding activity; iron ion binding activity; and oxygen binding activity. Predicted to be involved in oxygen transport and response to hypoxia. Expressed in neurons and somatic nervous system.

sra-11

Caenorhabditis elegans

Predicted to enable olfactory receptor activity. Involved in detection of chemical stimulus involved in sensory perception and olfactory learning. Predicted to be located in membrane. Expressed in VC neuron; interneuron; pharyngeal neurons; and ventral ganglion.

dpy-6

Caenorhabditis elegans

Enables calmodulin binding activity.