hen-1

Caenorhabditis elegans

Predicted to enable transmembrane receptor protein tyrosine kinase activator activity. Involved in dauer larval development and nervous system process. Located in axon and neuronal cell body. Expressed in neurons; pharyngeal muscle cell; and vulva.

ttx-3

Caenorhabditis elegans

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including olfactory learning; regulation of developmental process; and response to temperature stimulus. Predicted to be located in nucleus. Expressed in head muscle; head neurons; and pharyngeal neurons. Is an ortholog of human LHX9 (LIM homeobox 9).

lim-8

Caenorhabditis elegans

Enables protein domain specific binding activity. Predicted to be involved in positive regulation of stress fiber assembly and regulation of focal adhesion assembly. Located in M band. Expressed in excretory canal; head neurons; non-striated muscle; spermatheca; and vulva. Is an ortholog of human LIMCH1 (LIM and calponin homology domains 1).

ttx-7

Caenorhabditis elegans

Predicted to enable inositol monophosphate 1-phosphatase activity and metal ion binding activity. Involved in chemotaxis; protein localization to synapse; and thermotaxis. Located in cytoplasm. Expressed in several structures, including coelomocyte; gonad; intestine; neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 59; bipolar disorder; and schizophrenia. Is an ortholog of human IMPA1 (inositol monophosphatase 1) and IMPA2 (inositol monophosphatase 2).

lim-7

Caenorhabditis elegans

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including gonad morphogenesis; head morphogenesis; and pharynx development. Located in nucleus. Expressed in several structures, including body wall musculature; head neurons; lumbar neurons; pharyngeal neurons; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including atrial fibrillation; diabetes mellitus (multiple); and heart septal defect (multiple). Is an ortholog of human ISL1 (ISL LIM homeobox 1) and ISL2 (ISL LIM homeobox 2).

ceh-14

Caenorhabditis elegans

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in neuron development; positive regulation of transcription by RNA polymerase II; and thermosensory behavior. Located in nucleus. Expressed in several structures, including hypodermal cell; neurons; somatic nervous system; spermatheca; and tail. Human ortholog(s) of this gene implicated in panhypopituitarism. Is an ortholog of human LHX3 (LIM homeobox 3).

mec-3

Caenorhabditis elegans

Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and transcription coactivator activity. Involved in several processes, including mechanosensory behavior; neuron projection organization; and positive regulation of transcription by RNA polymerase II. Part of RNA polymerase II transcription regulator complex. Expressed in VA neuron; touch receptor neurons; ventral nerve cord; and vulva. Is an ortholog of human LHX1 (LIM homeobox 1) and LHX5 (LIM homeobox 5).

lim-9

Caenorhabditis elegans

Enables protein domain specific binding activity. Located in M band. Expressed in several structures, including body wall musculature; excretory canal; non-striated muscle; spermatheca; and vulva. Is an ortholog of human FHL2 (four and a half LIM domains 2).

tag-273

Caenorhabditis elegans

Predicted to enable actin filament binding activity. Predicted to be involved in actin filament bundle assembly. Predicted to be located in actin cytoskeleton and plasma membrane. Is an ortholog of human LIMA1 (LIM domain and actin binding 1).

lim-4

Caenorhabditis elegans

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including cell differentiation; positive regulation of transcription by RNA polymerase II; and serotonin biosynthetic process. Located in nucleus. Expressed in several structures, including ABalpppppa; head muscle; head neurons; lumbar neurons; and somatic nervous system. Is an ortholog of human LHX6 (LIM homeobox 6) and LHX8 (LIM homeobox 8).