ttx-7

Caenorhabditis elegans

Predicted to enable inositol monophosphate 1-phosphatase activity and metal ion binding activity. Involved in chemotaxis; protein localization to synapse; and thermotaxis. Located in cytoplasm. Expressed in several structures, including coelomocyte; gonad; intestine; neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 59; bipolar disorder; and schizophrenia. Is an ortholog of human IMPA1 (inositol monophosphatase 1) and IMPA2 (inositol monophosphatase 2).

ddl-3

Caenorhabditis elegans

Predicted to be involved in mitochondrial respiratory chain complex III assembly. Predicted to be located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 2. Is an ortholog of human TTC19 (tetratricopeptide repeat domain 19).

Y47G6A.9

Caenorhabditis elegans

Predicted to be involved in transcription by RNA polymerase III. Predicted to be located in nucleus. Predicted to be part of RNA polymerase III complex. Is an ortholog of human POLR3G (RNA polymerase III subunit G) and POLR3GL (RNA polymerase III subunit GL).

Y48A5A.3

Caenorhabditis elegans

Predicted to be involved in mitochondrial respiratory chain complex III assembly. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 7. Is an ortholog of human UQCC2 (ubiquinol-cytochrome c reductase complex assembly factor 2).

rpac-19

Caenorhabditis elegans

Predicted to enable protein dimerization activity. Predicted to contribute to RNA polymerase I activity and RNA polymerase III activity. Predicted to be involved in transcription by RNA polymerase III and transcription elongation by RNA polymerase I. Predicted to be located in nucleus. Predicted to be part of RNA polymerase I complex and RNA polymerase III complex. Used to study obesity. Human ortholog(s) of this gene implicated in Treacher Collins syndrome 2. Is an ortholog of human POLR1D (RNA polymerase I and III subunit D).

W06E11.1

Caenorhabditis elegans

Predicted to be involved in tRNA transcription by RNA polymerase III. Predicted to be located in nucleus. Predicted to be part of RNA polymerase III complex. Is an ortholog of human POLR3E (RNA polymerase III subunit E).

rpc-25

Caenorhabditis elegans

Predicted to be involved in transcription initiation at RNA polymerase III promoter. Predicted to be located in nucleus. Predicted to be part of RNA polymerase III complex. Is an ortholog of human POLR3H (RNA polymerase III subunit H).

tftc-5

Caenorhabditis elegans

Predicted to enable DNA binding activity. Predicted to contribute to RNA polymerase III type 1 promoter sequence-specific DNA binding activity and RNA polymerase III type 2 promoter sequence-specific DNA binding activity. Predicted to be involved in transcription initiation at RNA polymerase III promoter. Predicted to be located in nucleus. Predicted to be part of transcription factor TFIIIC complex. Is an ortholog of human GTF3C5 (general transcription factor IIIC subunit 5).

ttx-1

Caenorhabditis elegans

Enables DNA-binding transcription factor activity and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including positive regulation of transcription by RNA polymerase II; regulation of plasma membrane bounded cell projection assembly; and thermosensory behavior. Located in nucleus. Expressed in head neurons and pharyngeal cell. Human ortholog(s) of this gene implicated in panhypopituitarism and syndromic microphthalmia 5. Is an ortholog of human OTX1 (orthodenticle homeobox 1).

W09C3.4

Caenorhabditis elegans

Predicted to be involved in transcription by RNA polymerase III. Predicted to be located in nucleus. Predicted to be part of RNA polymerase III complex. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Is an ortholog of human POLR3F (RNA polymerase III subunit F).