trxr-2

Caenorhabditis elegans

Enables thioredoxin-disulfide reductase (NADPH) activity. Predicted to be involved in cell redox homeostasis. Located in mitochondrion. Expressed in intestine; muscle cell; nervous system; and vulva. Used to study chromosome 22q11.2 deletion syndrome, distal. Human ortholog(s) of this gene implicated in familial glucocorticoid deficiency. Is an ortholog of human TXNRD2 (thioredoxin reductase 2).

efsc-1

Caenorhabditis elegans

Predicted to enable translation elongation factor activity. Involved in selenocysteine incorporation. Is an ortholog of human EEFSEC (eukaryotic elongation factor, selenocysteine-tRNA specific).

trxr-1

Caenorhabditis elegans

Predicted to enable thioredoxin-disulfide reductase (NADPH) activity. Involved in ecdysis, collagen and cuticulin-based cuticle. Predicted to be located in cytosol and mitochondrion. Expressed in several structures, including hypodermis; interfacial epithelial cell; intestine; pharynx; and vulva. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; colorectal adenoma; and colorectal carcinoma. Is an ortholog of human TXNRD3 (thioredoxin reductase 3).

gsr-1

Caenorhabditis elegans

Enables glutathione-disulfide reductase (NADPH) activity. Involved in several processes, including cell redox homeostasis; ecdysis, collagen and cuticulin-based cuticle; and response to superoxide. Located in cytosol and mitochondrion. Expressed in several structures, including Epr; Epra; coelomocyte; excretory canal; and hermaphrodite gonad. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; cataract (multiple); hematologic cancer (multiple); and microcytic anemia (multiple). Is an ortholog of human GSR (glutathione-disulfide reductase).