spe-41

Caenorhabditis elegans

Enables store-operated calcium channel activity. Involved in calcium ion transport; intracellular calcium ion homeostasis; and single fertilization. Located in cytoplasmic vesicle and pseudopodium membrane. Expressed in sperm and spermatid.

trp-1

Caenorhabditis elegans

Predicted to enable inositol 1,4,5 trisphosphate binding activity and store-operated calcium channel activity. Predicted to be involved in calcium ion transmembrane transport; regulation of cytosolic calcium ion concentration; and single fertilization. Predicted to be located in plasma membrane. Predicted to be part of cation channel complex. Expressed in neurons and non-striated muscle. Used to study nicotine dependence. Human ortholog(s) of this gene implicated in several diseases, including cerebellar ataxia type 41; chronic fatigue syndrome; and focal segmental glomerulosclerosis 2. Is an ortholog of human TRPC3 (transient receptor potential cation channel subfamily C member 3); TRPC6 (transient receptor potential cation channel subfamily C member 6); and TRPC7 (transient receptor potential cation channel subfamily C member 7).

trp-2

Caenorhabditis elegans

Predicted to enable inositol 1,4,5 trisphosphate binding activity and store-operated calcium channel activity. Predicted to be involved in calcium ion transmembrane transport and regulation of cytosolic calcium ion concentration. Predicted to be located in plasma membrane. Predicted to be part of cation channel complex. Expressed in ASER; SMDDL; SMDDR; SMDVL; and SMDVR. Used to study nicotine dependence. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1H; lung cancer; and stomach cancer. Is an ortholog of human TRPC4 (transient receptor potential cation channel subfamily C member 4) and TRPC5 (transient receptor potential cation channel subfamily C member 5).

trp-4

Caenorhabditis elegans

Predicted to enable calcium channel activity. Predicted to be involved in sensory perception of mechanical stimulus. Predicted to be located in membrane. Expressed in dopaminergic neurons; dorsal-rectal ganglion neurons; head mesodermal cell; mechanosensory neurons; and rectum. Is an ortholog of human ANKRD28 (ankyrin repeat domain 28) and ANKRD44 (ankyrin repeat domain 44).

gon-11

Caenorhabditis elegans

trpa-2

Caenorhabditis elegans

Predicted to enable transmembrane transporter activity. Predicted to be involved in monoatomic ion transmembrane transport. Predicted to be located in membrane. Predicted to be part of transmembrane transporter complex. Expressed in ASEL; ASER; and neurons.

cup-5

Caenorhabditis elegans

Predicted to enable NAADP-sensitive calcium-release channel activity and phosphatidylinositol-3,5-bisphosphate binding activity. Involved in several processes, including cuticle development involved in collagen and cuticulin-based cuticle molting cycle; determination of adult lifespan; and lysosomal lumen acidification. Located in endolysosome and lysosomal membrane. Expressed in coelomocyte; head; intestinal cell; and neurons. Used to study mucolipidosis type IV. Human ortholog(s) of this gene implicated in glycoproteinosis and mucolipidosis type IV. Is an ortholog of human MCOLN1 (mucolipin TRP cation channel 1); MCOLN2 (mucolipin TRP cation channel 2); and MCOLN3 (mucolipin TRP cation channel 3).

ZK909.3

Caenorhabditis elegans

Predicted to enable guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity. Is an ortholog of human HDDC3 (HD domain containing 3).

sup-28

Caenorhabditis elegans

Expressed in body wall musculature; hermaphrodite gonad; hypodermis; intestine; and vulva.

ags-3

Caenorhabditis elegans

Enables G-protein alpha-subunit binding activity. Involved in regulation of feeding behavior. Located in membrane. Expressed in several structures, including hermaphrodite gonad; intestine; muscle cell; neurons; and tail. Human ortholog(s) of this gene implicated in sensorineural hearing loss. Is an ortholog of human GPSM1 (G protein signaling modulator 1) and GPSM2 (G protein signaling modulator 2).