Enables DNA topoisomerase type I (single strand cut, ATP-independent) activity. Involved in DNA topological change. Located in nucleus. Human ortholog(s) of this gene implicated in autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 5. Is an ortholog of human TOP3A (DNA topoisomerase III alpha).
Enables DNA topoisomerase type I (single strand cut, ATP-independent) activity. Predicted to be involved in DNA replication; DNA topological change; and chromosome segregation. Located in nucleolus and spindle pole centrosome. Expressed in several structures, including IL socket cell; excretory cell; gonad; intestine; and neurons. Is an ortholog of human TOP1 (DNA topoisomerase I) and TOP1MT (DNA topoisomerase I mitochondrial).
Enables 3'-5' DNA helicase activity and enzyme binding activity. Involved in several processes, including determination of adult lifespan; meiotic nuclear division; and resolution of DNA recombination intermediates. Located in chromosome and nucleus. Used to study Bloom syndrome. Human ortholog(s) of this gene implicated in Bloom syndrome. Is an ortholog of human BLM (BLM RecQ like helicase).
Predicted to enable hydroxymethylglutaryl-CoA lyase activity. Predicted to be involved in L-leucine catabolic process and ketone body biosynthetic process. Human ortholog(s) of this gene implicated in amino acid metabolic disorder. Is an ortholog of human HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase) and HMGCLL1 (3-hydroxy-3-methylglutaryl-CoA lyase like 1).