Enables acetylcholine-gated monoatomic cation-selective channel activity. Involved in several processes, including calcium ion import across plasma membrane; cholinergic synaptic transmission; and regulation of multicellular organismal process. Located in neuromuscular junction and postsynaptic membrane. Expressed in ganglia; head muscle; motor neurons; non-striated muscle; and ventral nerve cord. Used to study alcohol use disorder and congenital myasthenic syndrome. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; autosomal dominant nocturnal frontal lobe epilepsy (multiple); congenital myasthenic syndrome (multiple); and lung disease (multiple). Is an ortholog of human CHRNA2 (cholinergic receptor nicotinic alpha 2 subunit); CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit); and CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit).
Predicted to enable hydroxymethylglutaryl-CoA lyase activity. Predicted to be involved in L-leucine catabolic process and ketone body biosynthetic process. Human ortholog(s) of this gene implicated in amino acid metabolic disorder. Is an ortholog of human HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase) and HMGCLL1 (3-hydroxy-3-methylglutaryl-CoA lyase like 1).