ant-1.1

Caenorhabditis elegans

Predicted to enable ATP:ADP antiporter activity. Involved in determination of adult lifespan; mitochondrion organization; and positive regulation of apoptotic process. Located in mitochondrion. Expressed in several structures, including body wall musculature; hermaphrodite somatic gonadal cell; intestine; pharynx; and vulva. Used to study mitochondrial metabolism disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 2; facioscapulohumeral muscular dystrophy; intrinsic cardiomyopathy (multiple); and mitochondrial DNA depletion syndrome (multiple). Is an ortholog of human SLC25A4 (solute carrier family 25 member 4); SLC25A5 (solute carrier family 25 member 5); and SLC25A6 (solute carrier family 25 member 6).

mir-61

Caenorhabditis elegans

Involved in miRNA-mediated post-transcriptional gene silencing and regulation of vulval development. Expressed in several structures, including P5.p hermaphrodite; P5.pa; P5.pp; P7.p hermaphrodite; and P7.pa.

egli-1

Caenorhabditis elegans

Predicted to be involved in autophagosome assembly. Predicted to be located in endoplasmic reticulum membrane. Expressed in head; neurons; spermatheca; and vulva. Is an ortholog of human TMEM41B (transmembrane protein 41B).

lin-61

Caenorhabditis elegans

Predicted to enable chromatin binding activity and methylated histone binding activity. Involved in vulval development. Located in nucleus. Part of chromatin. Expressed widely. Is an ortholog of human L3MBTL2 (L3MBTL histone methyl-lysine binding protein 2) and MBTD1 (mbt domain containing 1).

tag-10

Caenorhabditis elegans

Located in membrane raft. Expressed in amphid neurons.

tag-120

Caenorhabditis elegans

Predicted to be involved in negative regulation of apoptotic signaling pathway. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and membrane. Expressed in excretory system; neurons; and pharyngeal muscle cell. Is an ortholog of human GRINA (glutamate ionotropic receptor NMDA type subunit associated protein 1).

hdl-2

Caenorhabditis elegans

Predicted to enable carboxy-lyase activity. Predicted to be involved in amino acid metabolic process and carboxylic acid metabolic process. Predicted to be located in cytoplasm.

cdap-2

Caenorhabditis elegans

Predicted to be involved in actin filament organization and cell migration. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 3 and immunodeficiency 61. Is an ortholog of human CD2AP (CD2 associated protein).

F14D2.11

Caenorhabditis elegans

Predicted to enable protein tag activity and ubiquitin protein ligase binding activity. Predicted to be involved in modification-dependent protein catabolic process and protein ubiquitination.

F52C6.2

Caenorhabditis elegans

Predicted to enable protein tag activity and ubiquitin protein ligase binding activity. Predicted to be involved in modification-dependent protein catabolic process and protein ubiquitination.