sym-1

Caenorhabditis elegans

Located in extracellular space. Expressed in vulB1 and vulB2.

sym-4

Caenorhabditis elegans

Enriched in several structures, including ABalapapap; ABalapppap; excretory cell; head mesodermal cell; and neurons based on microarray; tiling array; RNA-seq; and single-cell RNA-seq studies. Is affected by several genes including nuo-6; cua-1; and hsf-1 based on microarray; tiling array; and RNA-seq studies. Is affected by four chemicals including rotenone; stavudine; and fluvastatin based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domains: Phosphorylation site; WD40/YVTN repeat-like-containing domain superfamily; WD40 repeat; WD repeat-containing protein WDR44/Dgr2; WD domain, G-beta repeat; and WD40-repeat-containing domain superfamily. Is an ortholog of human WDR44 (WD repeat domain 44). Human WDR44 enables molecular sequestering activity and small GTPase binding activity.

sym-3

Caenorhabditis elegans

Enriched in several structures, including ABalapapapa; ABalapppapa; ABplpaaappa; ABprpaaappa; and neurons based on RNA-seq and single-cell RNA-seq studies. Is affected by several genes including cyc-1; isp-1; and mrps-5 based on microarray; RNA-seq; and tiling array studies. Is affected by eight chemicals including lithium chloride; Zidovudine; and allantoin based on microarray and RNA-seq studies. Is predicted to encode a protein with the following domains: EEIG1/2-like; N-terminal C2 in EEIG1 and EHBP1 proteins; and NT-type C2 domain. Is an ortholog of human EEIG1 (estrogen-induced osteoclastogenesis regulator 1) and EEIG2 (EEIG family member 2).

rpap-2

Caenorhabditis elegans

Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. Is an ortholog of human RPAP2 (RNA polymerase II associated protein 2).

sym-2

Caenorhabditis elegans

Predicted to enable mRNA binding activity. Involved in embryo development; embryonic body morphogenesis; and multicellular organismal movement. Predicted to be located in nucleoplasm. Predicted to be part of ribonucleoprotein complex. Used to study neurodegenerative disease. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 109. Is an ortholog of human ESRP1 (epithelial splicing regulatory protein 1) and ESRP2 (epithelial splicing regulatory protein 2).

crn-6

Caenorhabditis elegans

Enables deoxyribonuclease II activity. Involved in apoptotic DNA fragmentation. Is an ortholog of human DNASE2B (deoxyribonuclease 2 beta).

ceh-1

Caenorhabditis elegans

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in DVC; lateral ganglion; and seam cell. Is an ortholog of human NKX1-1 (NK1 homeobox 1) and NKX1-2 (NK1 homeobox 2).

efl-2

Caenorhabditis elegans

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Expressed in dorsal nerve cord; head muscle; intestine; spermatheca; and ventral nerve cord. Is an ortholog of human E2F6 (E2F transcription factor 6).

aman-2

Caenorhabditis elegans

Predicted to enable alpha-mannosidase activity. Predicted to be involved in N-glycan processing. Located in Golgi apparatus. Expressed in head; pharynx; and ventral nerve cord. Is an ortholog of human MAN2A2 (mannosidase alpha class 2A member 2).

C27F2.10

Caenorhabditis elegans

Predicted to enable RNA binding activity and double-stranded DNA binding activity. Predicted to be involved in poly(A)+ mRNA export from nucleus; post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery; and transcription elongation by RNA polymerase II. Predicted to be part of transcription export complex 2. Is an ortholog of human PCID2 (PCI domain containing 2).