mpk-1

Caenorhabditis elegans

Enables MAP kinase activity. Involved in several processes, including determination of adult lifespan; intracellular signaling cassette; and positive regulation of macromolecule metabolic process. Located in cytoplasm and nucleus. Expressed in F cell; U cell; germ line; gonad; and oocyte. Used to study cancer. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Noonan syndrome 13; carcinoma (multiple); and childhood pilocytic astrocytoma. Is an ortholog of human MAPK1 (mitogen-activated protein kinase 1).

sur-4

Caenorhabditis elegans

sur-7

Caenorhabditis elegans

Involved in several processes, including cellular response to zinc ion; muscle cell cellular homeostasis; and positive regulation of Ras protein signal transduction. Located in endoplasmic reticulum membrane. Expressed in several structures, including hypodermis; muscle cell; pharynx; tail; and vulva.

sur-6

Caenorhabditis elegans

Predicted to enable protein phosphatase regulator activity. Involved in embryo development; nematode larval development; and positive regulation of vulval development. Predicted to be located in cytosol. Predicted to be part of protein phosphatase type 2A complex. Human ortholog(s) of this gene implicated in Alzheimer's disease; breast cancer; spinocerebellar ataxia type 12; and systemic lupus erythematosus. Is an ortholog of human PPP2R2A (protein phosphatase 2 regulatory subunit Balpha) and PPP2R2D (protein phosphatase 2 regulatory subunit Bdelta).

sur-5

Caenorhabditis elegans

Predicted to enable acetoacetate-CoA ligase activity. Predicted to be involved in fatty acid metabolic process. Predicted to be located in cytoplasm and nucleus. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; gonad; hypodermal cell; and somatic cell. Is an ortholog of human AACS (acetoacetyl-CoA synthetase).

sur-2

Caenorhabditis elegans

Involved in defense response to Gram-positive bacterium; regulation of protein catabolic process; and regulation of transcription by RNA polymerase II. Part of mediator complex. Expressed in several structures, including P1.p; P2.p; P5.ppp; P7.paa; and vulval cell. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 18. Is an ortholog of human MED23 (mediator complex subunit 23).

sli-3

Caenorhabditis elegans

haly-1

Caenorhabditis elegans

Predicted to enable histidine ammonia-lyase activity. Involved in L-histidine catabolic process. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in histidinemia. Is an ortholog of human HAL (histidine ammonia-lyase).

dsl-1

Caenorhabditis elegans

Enables Notch binding activity. Predicted to be involved in cell fate specification. Predicted to be located in plasma membrane. Expressed in several structures, including P6.paa; P6.pap; P6.ppa; P6.ppp; and vulval cell.

cdf-1

Caenorhabditis elegans

Enables protein kinase binding activity. Involved in cellular response to zinc ion; positive regulation of Ras protein signal transduction; and positive regulation of vulval development. Located in basolateral plasma membrane. Expressed in several structures, including P5.ppp; P7.paa; rectal valve cell; vulval cell; and vulval muscle. Human ortholog(s) of this gene implicated in hypermanganesemia with dystonia 1. Is an ortholog of human SLC30A1 (solute carrier family 30 member 1).