ulp-1

Caenorhabditis elegans

Predicted to enable deSUMOylase activity. Involved in several processes, including embryo development; positive regulation of error-prone translesion synthesis; and protein desumoylation. Predicted to be located in nucleus. Is an ortholog of human SENP2 (SUMO specific peptidase 2).

aos-1

Caenorhabditis elegans

Contributes to SUMO activating enzyme activity. Involved in protein sumoylation. Predicted to be located in cytoplasm. Predicted to be part of SUMO activating enzyme complex. Is an ortholog of human SAE1 (SUMO1 activating enzyme subunit 1).

T04A8.8

Caenorhabditis elegans

Enriched in ABaraapapp; ABaraappaa; ABaraapppp; germ line; and hypodermis based on tiling array; RNA-seq; and single-cell RNA-seq studies. Is affected by several genes including atfs-1; etr-1; and hsp-6 based on microarray; proteomic; and RNA-seq studies. Is affected by eleven chemicals including rotenone; manganese chloride; and Zidovudine based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domains: Ubiquitin-like domain superfamily; Rad60/SUMO-like domain; Ubiquitin-2 like Rad60 SUMO-like; and Phosphorylation site.

ulp-3

Caenorhabditis elegans

Predicted to enable deNEDDylase activity. Predicted to be involved in protein deneddylation. Is an ortholog of human SENP8 (SUMO peptidase family member, NEDD8 specific).

uba-2

Caenorhabditis elegans

Enables SUMO activating enzyme activity. Involved in several processes, including anterior/posterior pattern specification; nematode larval development; and protein sumoylation. Predicted to be located in cytoplasm. Predicted to be part of SUMO activating enzyme complex. Is an ortholog of human UBA2 (ubiquitin like modifier activating enzyme 2).

R06C7.2

Caenorhabditis elegans

Predicted to enable SUMO transferase activity. Predicted to be involved in homologous chromosome pairing at meiosis and protein sumoylation. Predicted to be located in synaptonemal complex.

ZK1248.11

Caenorhabditis elegans

Predicted to enable SUMO ligase activity. Predicted to be involved in double-strand break repair via homologous recombination and protein sumoylation. Predicted to be located in nucleus. Predicted to be part of Smc5-Smc6 complex. Human ortholog(s) of this gene implicated in Seckel syndrome 10. Is an ortholog of human NSMCE2 (NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase).

gei-17

Caenorhabditis elegans

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and SUMO ligase activity. Involved in several processes, including meiotic metaphase I homologous chromosome alignment; protein sumoylation; and regulation of cellular response to stress. Located in metaphase plate. Part of chromatin. Expressed in motor neurons. Is an ortholog of human PIAS1 (protein inhibitor of activated STAT 1); PIAS2 (protein inhibitor of activated STAT 2); and PIAS3 (protein inhibitor of activated STAT 3).

rad-54.L2

Caenorhabditis elegans

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and SUMO binding activity. Involved in negative regulation of vulval development. Predicted to be located in nucleus. Predicted to be part of NuRD complex. Is an ortholog of human RAD54L2 (RAD54 like 2).

zhp-3

Caenorhabditis elegans

Predicted to enable SUMO transferase activity. Involved in embryo development; meiotic chromosome segregation; and synaptonemal complex disassembly. Located in synaptonemal complex. Is an ortholog of human RNF212B (ring finger protein 212B).