plin-1

Caenorhabditis elegans

Involved in embryo development. Predicted to be located in lipid droplet. Expressed in germ line; hypodermal cell; and intestinal cell.

sur-7

Caenorhabditis elegans

Involved in several processes, including cellular response to zinc ion; muscle cell cellular homeostasis; and positive regulation of Ras protein signal transduction. Located in endoplasmic reticulum membrane. Expressed in several structures, including hypodermis; muscle cell; pharynx; tail; and vulva.

syx-5

Caenorhabditis elegans

Predicted to enable SNAP receptor activity and SNARE binding activity. Predicted to be involved in intracellular protein transport and vesicle-mediated transport. Predicted to be located in Golgi membrane. Predicted to be part of SNARE complex. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II. Is an ortholog of human STX5 (syntaxin 5).

rab-8

Caenorhabditis elegans

Enables GTPase activating protein binding activity and ankyrin repeat binding activity. Involved in several processes, including embryonic genitalia morphogenesis; negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; and protein secretion. Located in apical part of cell and cytoplasmic vesicle. Expressed in body wall musculature. Is an ortholog of human RAB8B (RAB8B, member RAS oncogene family).

sel-12

Caenorhabditis elegans

Predicted to enable endopeptidase activity. Involved in several processes, including apical protein localization; egg-laying behavior; and regulation of signal transduction. Located in perinuclear region of cytoplasm. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease 3; Alzheimer's disease 4; Pick's disease; dilated cardiomyopathy (multiple); and hidradenitis suppurativa. Is an ortholog of human PSEN1 (presenilin 1) and PSEN2 (presenilin 2).

cand-1

Caenorhabditis elegans

Involved in regulation of protein deneddylation. Located in nucleus. Expressed widely. Used to study cancer. Human ortholog(s) of this gene implicated in atrial fibrillation. Is an ortholog of human CAND1 (cullin associated and neddylation dissociated 1) and CAND2 (cullin associated and neddylation dissociated 2 (putative)).

ceh-10

Caenorhabditis elegans

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including egg-laying behavior; generation of neurons; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in ABalapppaa; CAN; head neurons; seam cell; and somatic nervous system. Human ortholog(s) of this gene implicated in eye disease (multiple). Is an ortholog of human VSX2 (visual system homeobox 2).

zyx-1

Caenorhabditis elegans

Enables DEAD/H-box RNA helicase binding activity. Involved in maintenance of synapse structure. Acts upstream of or within with a positive effect on smooth muscle contraction. Located in M band; nucleus; and striated muscle dense body. Expressed in head; hypodermis; muscle cell; neurons; and tail neurons. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Is an ortholog of human LPP (LIM domain containing preferred translocation partner in lipoma) and TRIP6 (thyroid hormone receptor interactor 6).

bet-1

Caenorhabditis elegans

Enables SUMO binding activity and lysine-acetylated histone binding activity. Involved in several processes, including multicellular organismal locomotion; muscle cell cellular homeostasis; and regulation of DNA-templated transcription. Located in chromosome; metaphase plate; and nucleus. Expressed in several structures, including hypodermal cell and seam cell. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); lymphoma (multiple); and male infertility (multiple). Is an ortholog of human BRD2 (bromodomain containing 2) and BRDT (bromodomain testis associated).

gon-1

Caenorhabditis elegans

Enables metallopeptidase activity. Involved in several processes, including endoplasmic reticulum to Golgi vesicle-mediated transport; muscle organ morphogenesis; and negative regulation of presynapse assembly. Predicted to be located in extracellular matrix. Expressed in amphid neurons; excretory cell; gonad; motor neurons; and muscle cell. Used to study obesity and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in rheumatoid arthritis. Is an ortholog of human ADAMTS20 (ADAM metallopeptidase with thrombospondin type 1 motif 20) and ADAMTS9 (ADAM metallopeptidase with thrombospondin type 1 motif 9).