csk-1

Caenorhabditis elegans

Enables protein tyrosine kinase activity. Involved in several processes, including feeding behavior; muscle cell development; and nematode larval development. Located in cell-cell junction and plasma membrane. Expressed in several structures, including anus; head neurons; hermaphrodite somatic gonadal cell; pharyngeal muscle cell; and vulval cell. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Is an ortholog of human CSK (C-terminal Src kinase).

src-2

Caenorhabditis elegans

Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Involved in nematode pharynx development. Predicted to be located in plasma membrane. Expressed in anus; pharyngeal muscle cell; and vulva. Used to study Goldenhar syndrome. Is an ortholog of human FRK (fyn related Src family tyrosine kinase).

src-1

Caenorhabditis elegans

Enables netrin receptor binding activity and non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including anatomical structure morphogenesis; axis specification; and establishment of mitotic spindle orientation. Located in contractile muscle fiber and phagocytic cup. Expressed in several structures, including anchor cell; anus; distal tip cell; head neurons; and vulval cell. Used to study Goldenhar syndrome. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; diabetes mellitus (multiple); gastrointestinal system cancer (multiple); and lung non-small cell carcinoma (multiple). Is an ortholog of human FYN (FYN proto-oncogene, Src family tyrosine kinase); SRC (SRC proto-oncogene, non-receptor tyrosine kinase); and YES1 (YES proto-oncogene 1, Src family tyrosine kinase).

gldi-9

Caenorhabditis elegans

Located in cell junction and striated muscle dense body. Is an ortholog of human KIAA1217 (KIAA1217) and SRCIN1 (SRC kinase signaling inhibitor 1).

ced-6

Caenorhabditis elegans

Enables clathrin adaptor activity and scavenger receptor binding activity. Involved in several processes, including engulfment of apoptotic cell; left/right axis specification; and positive regulation of distal tip cell migration. Located in cytoplasmic side of plasma membrane and phagocytic vesicle. Is an ortholog of human GULP1 (GULP PTB domain containing engulfment adaptor 1).

ced-2

Caenorhabditis elegans

Predicted to enable receptor tyrosine kinase binding activity and signaling adaptor activity. Involved in several processes, including engulfment of apoptotic cell; positive regulation of distal tip cell migration; and positive regulation of engulfment of apoptotic cell. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); chronic myeloid leukemia; and invasive ductal carcinoma. Is an ortholog of human CRK (CRK proto-oncogene, adaptor protein) and CRKL (CRK like proto-oncogene, adaptor protein).

gpr-1

Caenorhabditis elegans

Enables G-protein alpha-subunit binding activity and GDP-dissociation inhibitor activity. Predicted to be involved in cell division. Located in aster and cell cortex. Expressed in P lineage cell.

gpr-2

Caenorhabditis elegans

Enables GDP-dissociation inhibitor activity. Predicted to be involved in cell division. Located in aster and cell cortex. Expressed in P lineage cell.

sem-5

Caenorhabditis elegans

Enables epidermal growth factor receptor binding activity. Involved in several processes, including epidermal growth factor receptor signaling pathway; male genitalia development; and regulation of vulval development. Predicted to be located in cytoplasm; nucleoplasm; and plasma membrane. Predicted to be part of COP9 signalosome. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P5.p hermaphrodite; P7.p hermaphrodite; and P8.p hermaphrodite. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 114; breast cancer; and reproductive organ cancer (multiple). Is an ortholog of human GRB2 (growth factor receptor bound protein 2).

lin-5

Caenorhabditis elegans

Enables dynein complex binding activity. Involved in several processes, including gonad development; microtubule cytoskeleton organization; and regulation of protein localization. Located in cell cortex; condensed chromosome; and spindle.