uba-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable ubiquitin activating enzyme activity. Involved in several processes, including developmental process involved in reproduction; negative regulation of transcription by RNA polymerase II; and programmed cell death involved in cell development. Located in nucleus. Expressed in anterior hypodermis; germ line; midbody; neurons; and pharynx. Human ortholog(s) of this gene implicated in VEXAS syndrome and X-linked spinal muscular atrophy 2. Is an ortholog of human UBA1 (ubiquitin like modifier activating enzyme 1).